Sökning: "Neutrophils"

Visar resultat 21 - 25 av 403 avhandlingar innehållade ordet Neutrophils.

  1. 21. The Role Of Serum Amyloid A In Inflammatory Disease - Proinflammatory Mediator Or Inert Biomarker?

    Författare :Lena Björkman; Göteborgs universitet; []
    Nyckelord :neutrophils; serum amyloid A; rheumatoid arthritis;

    Sammanfattning : Abstract: Neutrophils are phagocytes of the innate immune system with prominent roles in host defense and are also believed to be important in autoimmune diseases such as rheumatoid arthritis (RA) by accumulating in inflamed joints and contribute to tissues destruction. Neutrophils differentiate in the bone-marrow and are mature cells when entering circulation with a cytoplasm packed with granules that contain toxic substances in addition to receptors that can be up-regulated to the cell surface during activation. LÄS MER

  3. 22. Neutrophil function in health and disease - role of intracellular radicals and galectin-3 as regulators of inflammation

    Författare :Martina Sundqvist; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neutrophils; reactive oxygen species; galectin-3; PFAPA;

    Sammanfattning : The focus for this PhD project has been to investigate neutrophil functions in different (inflammatory) settings with specific focus on phagocyte-derived intracellular reactive oxygen species (ROS) as well as neutrophil interaction with the inflammatory mediator galectin-3. Neutrophils, the most abundant leukocyte in human blood, have traditionally been viewed upon mainly as professional phagocytes, being able to degrade invading microbes, and thus essential in the defence against infection. LÄS MER

  4. 23. Studies of SIRPα-mediated regulation of neutrophil functions

    Författare :Åsa Stenberg; Janove Sehlin; Karl-Eric Magnusson; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; SIRPα; inflammation; adhesion; chemotaxis; apoptosis;

    Sammanfattning : Neutrophil granulocytes constitute the front line of defense in the innate immune response to invading microorganisms, but can also contribute to development of inflammatory disease and tissue destruction following e.g. myocardial infarction or stroke. LÄS MER

  5. 24. Modulatory role of IL-17 in airway inflammation

    Författare :Elin Silverpil; Göteborgs universitet; []
    Nyckelord :Respiratory medicine; Lung; IL-17; IL-23; Macrophages; Neutrophils; T cells; Apoptosis; Phagocytosis; Airways;

    Sammanfattning : IL-17 orchestrates the accumulation of neutrophils to sites of infection and the release of microbicidal substances, and therefore plays a critical role in the innate immune response to infection. IL-17 is also involved in certain chronic inflammatory diseases in which dysfunctional control of neutrophil accumulation and turnover constitutes an important pathogenic factor. LÄS MER

  7. 25. Recognition by leukocyte formyl peptide receptors. Promiscuous binding or pattern recognition?

    Författare :Johan Bylund; Göteborgs universitet; []
    Nyckelord :neutrophils; chemoattractant; FPRL1; NADPH-oxidase; LPS; priming; subcellular organelles; human; murine;

    Sammanfattning : Neutrophil granulocytes play an important role in the early stages of microbial infection. The neutrophils have to leave the blood stream and migrate out into the tissue where they phagocytose microbes and cell debris from damaged host tissues. LÄS MER