Sökning: "Neuromuscular diseases"
Visar resultat 11 - 15 av 35 avhandlingar innehållade orden Neuromuscular diseases.
11. Studies on cytokine mRNA expression in mononuclear cells in neuroimmunological diseases
Sammanfattning : Background: Multiple sclerosis (MS) is an inflammatory demyelinating disease of the central nervous system (CNS), characterized by perivascular accumulation of blood mononuclear cells (MNC) and patchy demyelination. High levels of circulating myelin antigen specific T and B cells, with an accumulation in cerebrospinal fluid (CSF), suggest the involvement of cytokines in the pathogenesis of MS. LÄS MER
12. Studies on co-stimulatory molecules, chemokines and chemokine receptors in neuroimmunological diseases
Sammanfattning : Background: Multiple sclerosis (MS) and myasthenia gravis (MG) are characterised by activation of T cells directed against self antigens. Such autoreactive T cells are considered to play a central role in destruction of myelin in MS and in damage of neuromuscular junctions in MG. LÄS MER
13. Amyotrophic lateral sclerosis and multiple sclerosis associated neuroinflammation : nationwide epidemiological studies on etiology, comorbidities, and treatment
Sammanfattning : Amyotrophic lateral sclerosis (ALS) is a relatively rare but fatal neurodegenerative disease characterized by progressive muscle paralysis, due to loss of upper and lower motor neurons. Signs of neuroinflammation have been reported in ALS, however it is still unknown whether neuroinflammation is a cause or a consequence of the motor neuron dysfunction. LÄS MER
14. Laminins and Congenital Muscular Dystrophy - From a Mouse Model to Gene Therapy of Laminin alpha2 chain deficiency?
Sammanfattning : Gene therapy holds great promise for treating many genetic diseases, including muscular dystrophies. Mutations in the gene encoding laminin alpha2 chain ? an extracellular protein prominently expressed in the neuromuscular system ? cause a severe neuromuscular disorder: congenital muscular dystrophy type 1A (MDC1A). LÄS MER
15. From brain to muscle and back : novel approaches to harness the benefits of exercise
Sammanfattning : As the world population is growing older and more sedentary every day, the need for new approaches to combat chronic diseases grows steadily. Physical exercise improves health and reduces the risk of developing a plethora of chronic diseases. LÄS MER
