Sökning: "Neurogenin2"

Visar resultat 6 - 7 av 7 avhandlingar innehållade ordet Neurogenin2.

  1. 6. Investigating a cell replacement therapy in the inner ear

    Författare :Zhengqing Hu; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Adult neural stem cell; Cell therapy; Differentiation; Dorsal root ganglion; Embryonic stem cell; Gene transfer; Hearing loss; Nerve growth factor; Neurogenin; Organ of Corti; Spiral ganglion; Transplantation;

    Sammanfattning : The mammalian auditory system is sensitive to genetic disorders, aging and injuries caused by overstimulation, ototoxic drugs and viral infections. Since the sensory epithelium (the organ of Corti) and the spiral ganglion neurons (SGNs) in adult mammalian do not regenerate spontaneously when they are damaged, a cell substitution strategy was proposed to compensate the function of the degenerated SGNs. LÄS MER

  3. 7. Regulation of midbrain dopaminergic neuron development by Wnts, sFRPs and bHLH proteins

    Författare :Julianna M V Kele-Olovsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Parkinson’s disease (PD) is a chronic neurodegenerative disorder. The main pathology is characterized by progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra leading to loss of striatal dopamine innervation. The knowledge about the fundamental mechanisms behind the degenerative process has been limited. LÄS MER