Sökning: "Neurochemistry"

Visar resultat 21 - 25 av 136 avhandlingar innehållade ordet Neurochemistry.

1. 21. Processing of the APP family by the α-secretases ADAM10 and TACE

   Författare :Kristin Jacobsen; Kerstin Iverfeldt; Lars Nilsson; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : Alzheimer’s disease (AD) is a progressive neurodegenerative disease, which is characterized by formation of amyloid plaques in the brain. The major constituent of these plaques is the hydrophobic peptide Aβ. Aβ accumulation is considered to be the main cause of the pathology seen in AD brains. LÄS MER

3. 22. Cell-penetrating peptides in protein mimicry and oligonucleotide delivery : Applications and mechanisms

   Författare :Henrik Johansson; Ülo Langel; Michael Gait; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; peptide; oligonucleotide; cell-penetrating peptide; PNA; splicing; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : The plasma membrane functions as a barrier, restricting entry of hydrophilic pharmaceutical agents. Cell-penetrating peptides (CPPs) are capable of transporting bioactive cargos into the cell and have consequently been extensively investigated for their mechanism of entry and capability to deliver various cargos spanning from peptides to plasmids. LÄS MER

4. 23. Cell-penetrating peptides as delivery vectors for oligonucleotides and proteins : Studies on applications and toxicity

   Författare :Peter Järver; Ülo Langel; Gilles Divita; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : Cell-penetrating peptides (CPPs) have for a little bit more than a decade been employed as delivery vectors for a wide range of cargoes, ranging from gold particles to entire plasmids. Although CPP are well studied and utilized in numerous publications, our knowledge about CPP mediated transport is still poor. LÄS MER

5. 24. Cell-penetrating peptides in cargo delivery : In vitro studies on uptake and in vivo studies on tumor targeting

   Författare :Helena Myrberg; Ülo Langel; Roland Brock; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurochemistry; Neurokemi; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Sammanfattning : The capability of cell-penetrating peptides (CPPs) to transport cargos over different cellular membranes both in vitro and in vivo have drawn major attention in the past decade. Three main topics on the application of CPPs have been studied in this thesis. LÄS MER

7. 25. Rational modifications of cell-penetrating peptides for drug delivery : Applications in tumor targeting and oligonucleotide delivery

   Författare :Maarja Mäe; Ülo Langel; Edvard Smith; Stockholms universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cell-penetrating peptide; oligonucleotide; drug delivery; tumor targeting; Neurochemistry; Neurokemi; Neurochemistry and Molecular Neurobiology; neurokemi med molekylär neurobiologi;

   Sammanfattning : High molecular weight biomolecules are becoming important in the development of new therapeutics. However, their size and nature creates a major limitation for their application – poor penetration through biological membranes. LÄS MER