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Visar resultat 1 - 5 av 13 avhandlingar som matchar ovanstående sökkriterier.

  1. 1. Pluripotent Stem Cells of Embryonic Origin : Applications in Developmental Toxicology

    Författare :Måns Jergil; Lennart Dencker; Aldert Piersma; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Embryonic stem cell; Microarray; Toxicogenomics; Valproic acid; Developmental toxicology; Teratogenicity; Neural tube defects; Histone deacetylase inhibitor; In vitro toxicology; Toxicology; Toxikologi; Toxicology; Toxikologi;

    Sammanfattning : General toxicity evaluation and risk assessment for human exposure is essential when developing new pharmaceuticals and chemicals. Developmental toxicology is an important part of this risk assessment which consumes large resources and many laboratory animals. LÄS MER

  3. 2. Transcriptomics and Proteomics Applied to Developmental Toxicology

    Författare :Kim Kultima; Lennart Dencker; Timothy Gant; Uppsala universitet; []
    Nyckelord :Toxicology; 2D-DIGE; Valproic acid; PBDE-99; Flame retardant; Neural tube defects; Microarray; In vivo; In vitro; Biomarker; Brain growth spurt; Normalization; Mouse embryo; Toxicogenomics; Toxikologi;

    Sammanfattning : Developmental toxicology is an important part of preclinical drug toxicology as well as environmental toxicology. Assessing reproductive and developmental toxicity is especially expensive and time demanding, since at least two generations of animals are needed in the tests. LÄS MER

  4. 3. Nano and Micro Patterned Organic Devices : From Neural Interfaces to Optoelectronic Devices

    Författare :Tobias Nyberg; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : This thesis describes fabrication methods for optoelectronic devices (light emitting diodes (LEDs) and photodiodes) and structures for neural interfacing (neural electrodes and nerve guidance structures) using semiconducting and conducting organic materials as the active elements. Special importance has been attached to the patterning and processing of these devices. LÄS MER

  5. 4. Altered embryonic environment and congenital malformations in diabetic pregnancy

    Författare :Parri Wentzel; Uppsala universitet; []
    Nyckelord :Abnormalities *etiology prevention control; Animals; Diabetes Mellitus; Experimental *pathology; Dietary Supplements; Female; Folic Acid *therapeutic use; Glucose *toxicity; Neural Tube Defects etiology prevention control; Pregnancy; Pregnancy in Diabetics *physiopathology; RNA genetics isolation purification; Rats; Research Support; Non-U.S. Gov t; Tail abnormalities embryology;

    Sammanfattning : .... LÄS MER

  7. 5. Early function of KCC2 and Wnt genes : cytoskeletal effects in neural stem cells

    Författare :Zachi Horn; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : From closure of the neural tube until formation of neuronal networks, cells undergo several crucial changes which depend on the expression of many important molecules. GABA, the principal inhibitory neurotransmitter in the adult nervous system, acts as an excitatory signal during embryonic development. LÄS MER