Sökning: "Neural Progenitor Cell"

Visar resultat 11 - 15 av 135 avhandlingar innehållade orden Neural Progenitor Cell.

1. 11. Transposable Elements in Neural Progenitor Cells

   Författare :Liana Fasching; Molekylär neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Transposable Elements; TRIM28; Epigenetic Regulation; Gene Expression; Neural Progenitor Cells;

   Sammanfattning : More than 90% of DNA does not code for proteins and for a long time these sequences were referred to as “junk DNA” due to their unknown purpose. With the advent of new technologies it is now known, that the non-coding part of the genome is of great importance for regulating gene expression and is therefore indispensable. LÄS MER

3. 12. Glioma as an Ecosystem : Studies of Invasion, Onco-miR Addiction and Mast Cell Infiltration

   Författare :Jelena Põlajeva; Bengt Westermark; Ingemar Ernberg; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; glioblastoma; mast cell; miR-21; RAP1; CXCL12; SOX2;

   Sammanfattning : Despite recent advances in oncology and extensive research efforts, gliomas remain essentially incurable. Glioblastoma multiforme (GBM, WHO grade IV) is the most common glioma and may arise de novo or progress from a lower-grade lesion. GBM is characterized by invasive growth, aberrant angiogenesis and necrosis. LÄS MER

4. 13. Downstream effects of master regulators in two brain diseases

   Författare :Sebastian Braun; Stamcellscentrum (SCC); []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Rett syndrome; brain tumor development; gene regulation; neural stem cells; cell of origin; BMI1;

   Sammanfattning : In paper one, we investigated how the pharmacological activation and inhibition of the glucocorticoid system affects lifespan and symptoms in a mouse model for RTT. We performed a long-term drug treatment study with the GR activator corticosterone and the GR inhibitor RU486 under which we measured the lifespan and onset of RTT-like symptoms of male Mecp2-null and female Mecp2 heterozygous mice in comparison to untreated mutant and to treated and untreated wild-type animals. LÄS MER

5. 14. Development and Applications of in vitro Models to Study Human Brain Evolution and Disease

   Författare :Daniela Grassi; Molekylär neurogenetik; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neural reprogramming; Neural differentiation; Brain development; Huntington s disease; Induced Neuron; Neural Progenitor Cell; Brain evolution;

   Sammanfattning : Neuroscience focusing on human development and disease has long been hampered due to ethical reasons, low tissue availability, and low translatability from animal models. To circumvent these obstacles, we have developed two methods for the investigation of human neural cells in culture. LÄS MER

7. 15. Generation of midbrain dopaminergic neurons in vivo and in vitro: the role of Neurogenin2

   Författare :Elin Andersson; Neurobiologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; Medicin människa och djur ; cell replacement; Parkinson?s; dopamine; neuronal specification; development; mesencephalon; TH; neuronal differentiation; proneural genes; transcription factors; bHLH; neurospheres; stem cell; progenitor cell;

   Sammanfattning : Parkinsons disease (PD) is a neurodegenerative disorder where dopaminergic neurons of the substantia nigra (SNc) in the mesencephalon are progressively eliminated. The ensuing loss of dopaminergic innervation of the basal ganglia manifests itself as severe motor deficits in PD patients. LÄS MER