Sökning: "Nephropathy"

Visar resultat 1 - 5 av 93 avhandlingar innehållade ordet Nephropathy.

  1. 1. Novel Approaches to Treatment and Prevention of Diabetic Nephropathy

    Författare :Lina Nordquist; Mats Sjöquist; Peter Bergsten; William J. Welch; Uppsala universitet; []
    Nyckelord :Physiology; Diabetes; Nephropathy; C-peptide; Microneedle; Renal; GFR; Oxygen Consumption; Reabsorption; Fysiologi;

    Sammanfattning : Several studies have reported beneficial effects of C-peptide supplementation in diabetic patients and animal models of insulinopenic diabetes. However, it is also established that good glycemic control is essential to minimize the risk of diabetes-induced complications. LÄS MER

  3. 2. The role of hypoxia for the development of diabetic nephropathy : Temporal relationship and involvement of endothelin receptor signaling

    Författare :Stephanie Franzén; Fredrik Palm; Pamela K. Carmines; Linköpings universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nephropathy; diabetes; hypoxia; EPR;

    Sammanfattning : Diabetic nephropathy is one of the most common causes of end stage renal disease and develops in approximately one third of all diabetes patients. Disease progression is characterized by deteriorating glomerular filtration rate and escalating urinary albumin/protein excretion; both are used as clinical markers for disease progression. LÄS MER

  4. 3. Pathomechanism of diabetic nephropathy

    Författare :Anna Körner; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :diabetic nephropathy; hyperflltration; Na ; K - ATPase; Dahl rats; salt sensitive hypertension; glomerulosclerosis; polyol pathway activation; oxidative stress;

    Sammanfattning : Diabetic nephropathy is today the most common cause of end stage renal failure. The risk for developing overt diabetic nephropathy is considerably reduced by antihypertensive treatment, and adequate control of blood glucose. However, there is a need for additional and even more efficient tools to prevent this complication of diabetes. LÄS MER

  5. 4. Clinical and histopathologic studies in kidney transplant patients. With focus on IgA nephropathy

    Författare :Poul Michael Freese; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; IgA nephropathy; kidney transplantation; graft survival; histopathology; kidney biopsy; renal allograft biopsy; chronic allograft nephropathy; immunohistochemistry;

    Sammanfattning : .... LÄS MER

  7. 5. Membranous Nephropathy - Challenges in diagnostics and treatment

    Författare :Jennie Lönnbro-Widgren; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Glomerulonephritis; Membranous nephropathy; Proteinuria; Phospholipase A2 receptor; Cancer; End-stage renal disease;

    Sammanfattning : The variability in the pathogenesis, clinical presentation and outcome of membranous nephropathy (MN) poses major clinical challenges and raises different questions, both regarding diagnostics and treatment of patients with MN. The aims of this thesis were therefore to examine: 1) differences in the glomerular expression of different IgG subclasses and phospholipase A2 receptor (PLA2R) between patients with idiopathic and malignancy-associated MN; 2) treatment pattern of patients with idiopathic MN; and 3) if the serum PLA2R antibody level at diagnosis can be used as a prognostic marker. LÄS MER