Sökning: "Neoepitopes"

Hittade 3 avhandlingar innehållade ordet Neoepitopes.

  1. 1. Computational analysis on the effects of variations in T and B cells. Primary immunodeficiencies and cancer neoepitopes

    Författare :Gabriel Ndipagbornchi Teku; Proteinbioinformatik; []
    Nyckelord :Network topology; Network dynamics; network modeling; Network Simulation; T cells; B cells; Neoepitopes; Neoantigens; cancer;

    Sammanfattning : Computational approaches are essential to study the effects of inborn and somatic variations. Results from such studies contribute to better diagnosis and therapies. Primary immunodeficiencies (PIDs) are rare inborn defects of key immune response genes. Somatic variations are main drivers of most cancers. LÄS MER

  3. 2. Extracellular matrix in atherosclerotic plaques: its role in plaque stability

    Författare :Christoffer Tengryd; Kardiovaskulär forskning - translationella studier; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Extracellular matrix; Laminin; Collagen; Proteoglycans; Atherosclerosis; Carotid plaque; TGF-β;

    Sammanfattning : Atherosclerosis is a systemic disease affecting the large arteries caused by the accumulation of lipids in the vessel wall. Cardiovascular disease due to atherosclerosis is today the most common cause of death globally through its end consequences: myocardial infarctions and stroke. LÄS MER

  4. 3. 3D visualization of vascular lesions and the role of versican in pulmonary arterial hypertension

    Författare :Christian Westöö; Kärlväggsbiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pulmonary arterial hypertension; Synchrotron; Imaging; Phase-contrast; Plexiform; Versican;

    Sammanfattning : Pulmonary arterial hypertension (PAH) is a condition that leads to lethal right heart failure. Available treatments provide relief but are far from curative and the vascular remodeling in PAH has been difficult to decipher. LÄS MER