Sökning: "Negative frequency dependent selection"

Visar resultat 6 - 8 av 8 avhandlingar innehållade orden Negative frequency dependent selection.

  1. 6. Functional analysis of genetic variants in putative low penetrate breast cancer genes

    Författare :Haixin Lei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Breast cancer; low penetrance gene; CDH1; ILC; IDC; mutation; SNP; BA CHI; ATM; EST1; cryptic splice site; SR proteins; dinucleotide repeats; splicing silencer.;

    Sammanfattning : Paper I & II: CDH1 germline mutations predispose individuals to diffuse gastric cancer, but its role in breast cancer is less clear. Somatic CDH1 mutations were reported to be frequent in lobular tumours (ILC), but they have not been found in ductal carcinomas (IDC). LÄS MER

  3. 7. SNAP-25 and Cdk5 as exocytotic regulators : consequences for synaptic function and insulin release

    Författare :Jenny Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : The process by which cells release substances through fusion of vesicles with the plasma membrane is called exocytosis. Regulated exocytosis needs to be tightly controlled in order to respond to the large variation in stimuli and demands for release of neurotransmitters, peptides and hormones. LÄS MER

  4. 8. Dynamics of ecological communities in variable environments : local and spatial processes

    Författare :Linda Kaneryd; Bo Ebenman; Peter Münger; Michael S. Fowler; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : The ecosystems of the world are currently facing a variety of anthropogenic perturbations, such as climate change, fragmentation and destruction of habitat, overexploitation of natural resources and invasions of alien species. How the ecosystems will be affected is not only dependent on the direct effects of the perturbations on individual species but also on the trophic structure and interaction patterns of the ecological community. LÄS MER