Sökning: "Nef"

Visar resultat 1 - 5 av 14 avhandlingar innehållade ordet Nef.

  1. 1. Immune dysregulation in HIV-1 infected lymphoid tissue

    Författare :Homira Behbahani; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; HAART; cytokines; chemokines; lymphoid tissue; perforin; Nef; LIF; placenta; chemokine receptor;

    Sammanfattning : Lymphoid compartments are major sites for HIV-1 replication. We evaluated cytokines, chemokines and immunological effector function at the single cell level in lymphoid tissues in chronically HIV-1 infected patients. LÄS MER

  3. 2. Studies in DNA immunization

    Författare :Cecilia Svanholm; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Chlamydia pneumoniae; DNA vaccine; GM-CSF; HIV-1; hsp60; Nef; Rev; Tat; signal sequence;

    Sammanfattning : This thesis describes investigations and developments of DNA immunization techniques, which were applied in the study of two different pathogens; HIV-1 and Chlamydia pneumoniae. DNA vaccines, i.e. naked plasmid DNA encoding an antigen, represent a novel strategy for generating protective immunity against several infectious diseases. LÄS MER

  4. 3. Viral parameters influencing clinical long-term non progression in HIV-1 infected subjects

    Författare :Ubaldo Visco Comandini; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :LTNP; HIV-1 DNA; HIV-1 RNA; quantification; spontaneous decrease; genetic heterogeneity; nef; LTR; CCR5 deletion;

    Sammanfattning : A very small portion of the HIV-1 infected population is constituted by individuals, called long- term non progressors (LTNP), in whom after even a decade or more, no visible deterioration of the immune system is recognized and the infection remains therefore asymptomatic. The reasons for such "natural" prolonged well-being can be attributed to both the virus and the infected host and their understanding is likely to give important information for the development of an effective HIV- vaccine and for immune reconstitution therapy. LÄS MER

  5. 4. Complement aberrations and autoantibodies to complement proteins in relation to disease mechanisms

    Författare :Lillemor Melander Skattum; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; C3 nephritic factors; GM allotypes; C1q autoantibodies; serum bactericidal activity; Neisseria meningitidis; idiopathic sudden hearing loss; complement; Acute poststreptococcal glomerulonephritis;

    Sammanfattning : The complement system, a part of the innate immune system with several links to the adaptive immune system, plays an important role in the pathogenesis of many diseases. The purpose of this thesis was to document and clarify some of these mechanisms. The thesis is based on four papers (I-IV). LÄS MER

  7. 5. Enhancement of HIV-1 DNA immunogens

    Författare :Anne Kjerrström Zuber; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :HIV-1; DNA vaccination; regulatory genes; adjuvants; experimental HIV-1 model;

    Sammanfattning : Human immunodeficiency virus type 1 eludes control by the immune response through a high degree of variability and immune escape mechanisms. Induction of a broad specific immune response is important to clear virus-infected cells. LÄS MER