Sökning: "Naturvetenskap Data- och informationsvetenskap Bioinformatik beräkningsbiologi"

Visar resultat 1 - 5 av 20 avhandlingar innehållade orden Naturvetenskap Data- och informationsvetenskap Bioinformatik beräkningsbiologi.

1. 1. Integrating multi-omics for type 2 diabetes : Data science and big data towards personalized medicine

   Författare :Klev Diamanti; Jan Komorowski; Claes Wadelius; Manfred Grabherr; Peter Spégel; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; type 2 diabetes; multi-omics; genomics; metabolomics; data science; machine learning; personalized medicine; Bioinformatics; Bioinformatik;

   Sammanfattning : Type 2 diabetes (T2D) is a complex metabolic disease characterized by multi-tissue insulin resistance and failure of the pancreatic β-cells to secrete sufficient amounts of insulin. Cells recruit transcription factors (TF) to specific genomic loci to regulate gene expression that consequently affects the protein and metabolite abundancies. LÄS MER

3. 2. Patterns in big data bioinformatics : Understanding complex diseases with interpretable machine learning

   Författare :Mateusz Garbulowski; Jan Komorowski; Ryan J. Urbanowicz; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; complex diseases; big data; machine learning; transcriptomics; life sciences; rough sets; Bioinformatics; Bioinformatik;

   Sammanfattning : Alterations in the flow of genetic information may lead to complex diseases. Such changes are measured with various omics techniques that usually produce the so-called “big data”. Using interpretable machine learning (ML), we retrieved patterns from transcriptomics data sets. LÄS MER

4. 3. Computer Simulation of the Neural Control of Locomotion in the Cat and the Salamander

   Författare :Nalin Harischandra; Örjan Ekeberg; Silvia Gruhn; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Locomotion; Computer simulation; Central pattern generator; System identification; Gait transition; Sensory feedback; Spiking neural networks;

   Sammanfattning : Locomotion is an integral part of a whole range of animal behaviours. The basic rhythm for locomotion in vertebrates has been shown to arise from local networks residing in the spinal cord and these networks are known as central pattern generators (CPG). LÄS MER

5. 4. Computational Modelling of Gene Regulation in Cancer : Coding the noncoding genome

   Författare :Husen Muhammad Umer; Jan Komorowski; Claes Wadelius; Jan Korbel; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Regulatory elements; gene regulation; cancer; motif; integrative database; software solutions for cancer data; Bioinformatics; Bioinformatik;

   Sammanfattning : Technological advancements have enabled quantification of processes within and around us. The information stored within our body converts into petabytes of data. Processing and learning from such data requires comprehensive computational programs and software systems. LÄS MER

7. 5. Elucidation of complex diseases by machine learning

   Författare :Karolina Smolinska Garbulowska; Jan Komorowski; Claes Wadelius; Tuuli Lappalainen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; machine learning; complex disease; multi-omics; regulatory element; gene regulation; transcription factor motif; networks; rough sets; Bioinformatics; Bioinformatik;

   Sammanfattning : Uncovering the interpretability of models for complex health-related problems is a crucial task that is often neglected in machine learning (ML). The amount of available data makes the problem even more complicated. LÄS MER