Sökning: "Natural"

Visar resultat 21 - 25 av 29237 avhandlingar innehållade ordet Natural.

1. 21. Synthesis of bioactive natural products and analogues

   Författare :Dan Killander; Centrum för analys och syntes; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; SAR; natural product; total synthesis; benzochromene; fluorene; cannabinoid; statin; TRPA1; TSLP; antiprotozoal; nociception; asthma; inflammation;

   Sammanfattning : Natural products have until recently provided the only remedy for treatment of diseases. The development of modern chemistry in the last centuries has opened the door for tapping into the chemical diversity found in nature. Synthetic natural products, together with analogues, are an important piece in the puzzle towards curing many ailments. LÄS MER

3. 22. Discovery of Novel Macrocyclic Ligands for Difficult Targets : Applications to Natural Product Derived Keap1 Inhibitors

   Författare :Fabio Begnini; Jan Kihlberg; Anders Bach; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Macrocycles; Keap1-Nrf2; Protein-protein interactions; Natural products;

   Sammanfattning : The development of small-molecule ligands for biological targets that possess large, featureless or highly polar binding sites is a challenging task. This thesis is focused on a novel lead generation strategy to identify macrocyclic ligands for difficult-to-drug targets, as well as on the relationship between cell permeability and the conformations of macrocycles. LÄS MER

4. 23. Natural resources and sustainable energy : Growth rates and resource flows for low-carbon systems

   Författare :Simon Davidsson; Mikael Höök; Gert Jan Kramer; Uppsala universitet; []
   Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; low-carbon technology; renewable energy; energy transitions; critical materials; energy metals; material flows; net energy; EROI; life cycle assessment; LCA; growth curves; curve fitting; resource depletion; Natural Resources and Sustainable Development; Naturresurser och hållbar utveckling;

   Sammanfattning : Large-scale deployment of low-carbon energy technologies is important for counteracting anthropogenic climate change and achieving universal energy access. This thesis explores potential growth rates of technologies necessary to reach a more sustainable global energy system, the material and energy flows required to commission these technologies, and potential future availability of the required resources. LÄS MER

5. 24. Mechanisms regulating Natural Killer Cell Cytotoxicity

   Författare :Hanna van Ooijen; Björn Önfelt; Karl-Johan Malmberg; Karolin Guldevall; Morgan Huse; KTH; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Natural Killer cell; Live-cell microscopy; Single cell; 3D; Microwell;

   Sammanfattning : Over the last 50 years, cancer survival rates have steadily improved thanks to earlier detection and novel treatment regimens. For example, drugs that act on the immune system, so-called immunotherapy, have drastically increased the prospect of survival for patients suffering from some of the most aggressive cancer types including advanced malignant melanoma. LÄS MER

7. 25. Dialogue and revolution : fostering legitimate stakeholder agency in natural resource governance

   Författare :Rasmus Klocker Larsen; C. Leeuwis; Neil Dr.; Wageningen University; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; natural resources; resource management; stakeholders; participation; governance;

   Sammanfattning : This thesis explores how people exert their agency in policy processes that pertain to natural resource governance, and how they construct the required sense of legitimacy for such actions. It also examines the manner in which facilitated multi-stakeholder processes foster legitimate stakeholder agency, and reflects on how they may ensure the rigour of research interventions in situations characterised by intractable uncertainty and controversy. LÄS MER