Sökning: "Natural product"
Visar resultat 1 - 5 av 1134 avhandlingar innehållade orden Natural product.
1. Digital Product Innovation : Building Generative Capability through Architectural Frames
Sammanfattning : Over the last decades we have witnessed a profound digitalization of tangible products. While this shift offers great opportunities, it also exposes product developing industries to significant challenges. LÄS MER
2. Stereoselective Synthesis of Amino Alcohols : Applications to Natural Product Synthesis
Sammanfattning : This thesis is divided into four separate parts with amino alcohols as the common feature. The first part of the thesis describes the development of an efficient three-component approach to the synthesis of α-hydroxy-β-amino esters. LÄS MER
3. Discovery of Novel Macrocyclic Ligands for Difficult Targets : Applications to Natural Product Derived Keap1 Inhibitors
Sammanfattning : The development of small-molecule ligands for biological targets that possess large, featureless or highly polar binding sites is a challenging task. This thesis is focused on a novel lead generation strategy to identify macrocyclic ligands for difficult-to-drug targets, as well as on the relationship between cell permeability and the conformations of macrocycles. LÄS MER
4. Resource efficient products in a circular economy – The case of consumables. From environmental and resource assessment to design guidelines
Sammanfattning : The circular economy (CE) is a concept to challenge the unsustainable production, consumption, and waste management of products, through the recirculation of resources and products through various means while reducing environmental impact. Within this concept, many measures are recommended for reducing environmental impact and resource use. LÄS MER
5. Synthesis Towards Biologically Active Natural Products
Sammanfattning : In 2005 two research groups independently reported the isolation of a series of structurally intriguing C-19 terpenolides from the plants Thapsia transtagana and Thapsia garganica. The compounds were shown to be potent inhibitors of the sarco/endoplasmic reticulum Ca2+-ATPases. LÄS MER
