Sökning: "NanoSIMS"

Visar resultat 1 - 5 av 6 avhandlingar innehållade ordet NanoSIMS.

  1. 1. Quantitative NanoSIMS provides subcellular concentration and distribution of oligonucleotide therapeutics

    Författare :Cécile Becquart; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NanoSIMS; Antisense Oligonucleotide; Intracellular concentration;

    Sammanfattning : Antisense oligonucleotides (ASOs) represent a powerful therapeutic modality that can selectively modulate gene expression. However, ASOs face two major hurdles that restrict their use in the clinic. The first issue is delivery of the ASO to a tissue of therapeutic interest while reducing exposure to unrelated tissues. LÄS MER

  3. 2. Quantitative chemical imaging to study content release from single nanovesicles

    Författare :Tho D. K. Nguyen; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Exocytosis; Vesicle; Mass spectrometry imaging; Electron microscopy; Fluorescence microscopy; Electrochemical analysis; NanoSIMS;

    Sammanfattning : Cellular communication is vital for the survival of multicellular organisms. This process often relies on a highly regulated mechanism called exocytosis, which involves the release of chemical signals. During exocytosis, vesicles can fully or partially release their contents. LÄS MER

  4. 3. PROBING SECRETORY VESICLES AND LIPOSOME MODEL SYSTEMS USING NANOSCALE ELECTROCHEMISTRY AND MASS SPECTROMETRY

    Författare :Jelena Lovric; Chalmers tekniska högskola; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; neuroendocrine cells; NanoSIMS; liposomes; neurotransmitters; large dense core vesicles; Exocytosis; ToF-SIMS; vesicle electrochemical cytometry; electrochemistry; amperometry;

    Sammanfattning : Cellular communication is based on the process of exocytosis, regulated release of chemical messengers into the extracellular space. These messengers, neurotransmitters, are packed into vesicles that during exocytosis fuse with the plasma membrane and release their content. LÄS MER

  5. 4. Multimodal Chemical Imaging of Amyloid Plaque Pathology in Alzheimer’s Disease

    Författare :Wojciech Michno; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; beta-amyloid; electron microscopy; imaging mass spectrometry; lipids; luminescent conjugated oligothiophenes; matrix-assisted laser desorption ionization mass spectrometry MALDI-MS ; molecular imaging; nanoscale secondary ion mass spectrometry NanoSIMS ; neurodegeneration; peptides;

    Sammanfattning : Alzheimer’s disease (AD) is the most common form of dementia. AD has been linked to the aggregation of amyloid beta (Aβ) peptides into extracellular deposits, Aβ plaques. These are also found in cognitively unimpaired amyloid-positive (CU-AP) individuals, but these Aβ plaques are primarily diffuse in structure. LÄS MER

  7. 5. Correlative Chemical Imaging of Nanoscale Subcellular Structures

    Författare :Stefania Rabasco; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : Chemical imaging can elucidate complex mechanisms, relationships, and components of biological samples. For example, it can reveal properties such as chemical composition, chemical structure, reactivity, and topography. Several imaging techniques exist, each providing different types of information. LÄS MER