Sökning: "NSCLC"
Visar resultat 11 - 15 av 46 avhandlingar innehållade ordet NSCLC.
11. An integrative strategy for targeted evaluation of biomarker expression in non-small cell lung cancer
Sammanfattning : Despite improvements in therapy, the prognosis for non-small cell lung cancer (NSCLC) patients remains poor, and cure is only possible in localized tumors after surgical resection. A new generation of targeted cancer drugs has led to the expectation that lung cancer therapy can be significantly improved, but these drugs are today only an option in a small subset of NSCLC patients, and their effect is temporary. LÄS MER
12. LRIG1 in lung cancer : prognostic effects and mechanistic studies
Sammanfattning : Lung cancer is the leading cause of cancer-related death worldwide as well as in Sweden. Non-small cell lung cancer (NSCLC) is the predominant form, which is largely subdivided into adenocarcinomas and squamous cell carcinomas. LÄS MER
13. Molecular Characterisation and Prognostic Biomarker Discovery in Human Non-Small Cell Lung Cancer
Sammanfattning : Non-small cell lung cancer (NSCLC) constitutes a clinically, histologically, and genetically heterogeneous disease entity that represents a major cause of cancer-related death. Early-stage patients, who undergo surgery with curative intent, experience high recurrence rates and the effect of adjuvant treatment is modest. LÄS MER
14. MicroRNAs : significance for sensitivity/resistance of lung cancer cells to treatment
Sammanfattning : Intrinsic or acquired resistance of lung cancer (LC) to chemo- or radiotherapy (CT/RT) limits the treatment effectiveness, which, in turn contributes to tumor progression and ultimately increases the mortality rate of the LC patients. Although resistance to tumor treatment is a multifactorial event for which several factors were identified, still many critical features underlying the mechanisms of resistance remain elusive. LÄS MER
15. The use of IGF-IR inhibitors in cancer therapy : a potential approach for sensitizing tumor cells to ionizing radiation
Sammanfattning : This study focused on insulin-like growth factor I receptor (IGF-IR), considered as a promising therapeutic target for cancer treatment. We were in particular interested in the involvement of IGF-IR in tumor cells response to radiation and we tried to provide the rationale for a combined therapy of IFG4R inhibitors with radiation in order to improve the therapeutic outcome. LÄS MER