Sökning: "NSAIDs"

Visar resultat 6 - 10 av 60 avhandlingar innehållade ordet NSAIDs.

  1. 6. An experimental study of mediators in allergic bronchoconstriction with focus on eicosanoids

    Författare :Ewa Selg; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Leukotrienes; prostaglandins; histamine; guinea pig lung; ovalbumin; mast cell; cyclooxygenase; airway smooth muscle; COX inhibitors; NSAIDs;

    Sammanfattning : Mast cells have a central role in the inflammatory response in airways of both atopic and non-atopic asthmatics. The mast cell-derived mediators such as histamine, leukotriene C4 and prostaglandin D2, released upon activation of the cell, produce acute bronchoconstriction that is characteristic of the early asthmatic response (EAR), and contribute to the development of airway inflammation and hyperresponsiveness following the initial reaction. LÄS MER

  3. 7. Medical interventions and gastric cancer risk : an observational approach

    Författare :Katja Fall; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Gastric cancer; cardia cancer; histological subtypes; H. pylori; antibiotic treatment; eradication; aspirin; NSAIDs; cholecystectomy; reactive gastritis; cohort; epidemiology;

    Sammanfattning : Helicobacter pylori infection is undoubtedly the most important risk factor for gastric cancer. A causal relationship with gastric cancer, however, has not been clearly established and the carcinogenic mechanism is still ambiguous. LÄS MER

  4. 8. Some lifestyle-related factors and risk of chronic renal failure : a population-based approach

    Författare :Elisabeth Ejerblad; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Epidemiology; population-based; case-control; chronic renal failure; risk factors; smoking; antioxidant; fruit; vegetable; protein intake; obesity; birth weight; height; analgesics; paracetamol; aspirin; NSAIDs; phenacetin;

    Sammanfattning : Some renal diseases, i.e. rapidly progressive glomerulonephritis, are sufficient causes of a rapid, permanent total loss of renal function. However, the majority of renal diseases progress slowly over decades, initially often without symptoms, sometimes making it difficult to define the aetiologies. LÄS MER

  5. 9. Non-Steroidal Anti-Inflammatory Drugs in Cyclooxygenases 1 and 2 : Binding modes and mechanisms from computational methods and free energy calculations

    Författare :Yasmin Shamsudin Khan; Johan Åqvist; Hugo Gutiérrez de Terán; Xavier Barril; Uppsala universitet; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; molecular dynamics simulations; binding free energy; molecular docking; cyclooxygenase; non-steroidal anti-inflammatory drugs; free energy perturbation; potentials of mean force;

    Sammanfattning : Non-steroidal anti-inflammatory drugs (NSAIDs) are one of the most commonly used classes of drugs. They target the cyclooxygenases (COX) 1 and 2 to reduce the physiological responses of pain, fever, and inflammation. Due to their role in inducing angiogenesis, COX proteins have also been identified as targets in cancer therapies. LÄS MER

  7. 10. Sorption and transformation of polar pharmaceuticals during wastewater treatment studied by hollow fiber liquid phase microextraction

    Författare :Estelle Larsson; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; pharmaceuticals; wastewater treatment; sludge; hollow fiber liquid phase microextraction;

    Sammanfattning : This thesis addresses the application of hollow fiber liquid phase microextraction as a simple, efficient and environmentally friendly tool to study the fate of four common anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) during wastewater treatment. Initial experiments verified that this technique is applicable on aqueous as well as suspensions of solid samples, thus greatly simplifying the sample preparation. LÄS MER