Sökning: "NS1"
Visar resultat 1 - 5 av 10 avhandlingar innehållade ordet NS1.
1. NA transmembrane domain : Amphiphilic drift to accommodate two functions
Sammanfattning : Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. LÄS MER
2. Immuno-regulatory dynamics of non-structural protein 1 of avian influenza A viruses : IFN-β, NF-κB and AP-1 perspectives
Sammanfattning : The type I interferon (IFN-α/β) system represents the first line of defense against influenza A viruses, and is mainly mediated by the interferon regulatory factors 3/7 (IRF3/7), nuclear factor kappa B (NF-κB) and activator protein 1 (AP-1) transcription factors. Therefore, the non-structural protein 1 (NS1) of influenza A viruses has intrinsic abilities to disarm the host cell IFN system, and as a consequence is deeply connected to influenza virus pathogenicity and virulence. LÄS MER
3. Roles of mammalian Scribble in polarity signaling, virus offense and cell-fate determination
Sammanfattning : Mammalian Scribble is a target for proteins encoded by human papilloma virus, retro- and flaviviruses. Tick-borne encephalitis virus (TBEV) is a flavivirus that have evolved distinct strategies to escape antiviral responses. LÄS MER
4. Development and evaluation of a subunit DIVA vaccine against bluetongue virus serotype 8 in cattle
Sammanfattning : Bluetongue virus (BTV) causes the primarily vector-borne bluetongue disease of ruminants, which poses a permanent threat to Europe since new serotypes and strains are frequently introduced. Vaccination of cattle is essential to control BTV outbreaks. LÄS MER
5. Novel treatments of glioblastoma in experimental models
Sammanfattning : One of the major problems with malignant brain tumours, such as glioblastoma multiforme, is that despite being able to remove the major bulk of the tumour through surgery and treating the patients with chemotherapy and radiotherapy, we know that tumour cells have already spread throughout the brain. Furthermore, we now know that the glioblastoma cells effectively suppress the patients’ own anti-tumour response. LÄS MER