Sökning: "NPL"

Visar resultat 1 - 5 av 11 avhandlingar innehållade ordet NPL.

  1. 1. Genetic susceptibility to psoriasis in Sweden

    Författare :Fredrik Enlund; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD80; CD86; joint complaints; linkage analysis; NPL; psoriasis; TDT; chromosome region 3q21;

    Sammanfattning : A common skin disease affecting about 2-3% of the population, psoriasis has an inheritance pattern that is unclear, but most probably many genes are involved in its pathogenesis. Other studies have suggested many susceptibility regions in the genome, but as yet independent studies have replicated only some of these regions located on chromosome 1q, 6p and 17q. LÄS MER

  3. 2. Pointwise and Genomewide Significance Calculations in Gene Mapping through Nonparametric Linkage Analysis: Theory, Algorithms and Applications

    Författare :Lars Ängquist; Matematisk statistik; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; programming; actuarial mathematics; Statistik; cytogenetics; Genetik; cytogenetik; Mathematics; Matematik; Statistics; operations research; Genetics; ROC curves; conditioning loci; optimal score functions; noncentrality parameter; cost adjusted relative efficiency; exponential tilting; importance sampling; Monte Carlo simulation; normal approximation; crossover rate; process maximum; analytical approximation; significance calculations; NPL score; conditional linkage analysis; two-locus linkage analysis; Allele sharing; aktuariematematik; operationsanalys; programmering; gene-gene interaction; composite hypotheses; genetic disease models; classes of score functions; nonparametric linkage analysis;

    Sammanfattning : In linkage analysis or, in a wider sense, gene mapping one searches for disease loci along a genome. This is done by observing so called marker genotypes (alleles) and phenotypes (affecteds/unaffecteds) of a pedigree set, i.e. LÄS MER

  4. 3. On Power Estimation and Score Predictions in Affected Sib-Pair Linkage Analysis

    Författare :Mikael Knutsson; Göteborgs universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; affected sib-pair; linkage analysis; nonparametric linkage score; sib prevalence; statistical genetics; nonparametric linkage score;

    Sammanfattning : This thesis consists of three papers in statistical genetics, with the emphasis on affected sib-pair linkage analysis. In Paper A, a method to derive the power of linkage analysis in genome scans, using a stepwise approach, is presented. LÄS MER

  5. 4. Natural Ventilation and Air Infiltration in Large Single‑Zone Buildings : Measurements and Modelling with Reference to Historical Churches

    Författare :Abolfazl Hayati; Magnus Mattsson; Mats Sandberg; Jens Fransson; Guilherme Carrilho da Graça; Högskolan i Gävle; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Natural ventilation; Airing; Air infiltration; Single-sided ventilation; Cross flow; Large single zones; Historical Churches; Model evaluation optimization; Field measurements; Wind tunnel; Indoor climate and Energy simulation; IDA-ICE; Tracer gas technique; Pressurization test.; Naturlig ventilation; Vädring; Luftinfiltration; Ensidig ventilation; Tvärdrag; Höga en-zonsbyggnader; Kulturhistoriska kyrkor; Modellutvärdering optimering; Fältmätningar; Vindtunnel; Inomhusklimat och energisimulering; IDA-ICE; Spårgas teknik; Trycksättningstest.; Hållbar stadsutveckling; Sustainable Urban Development;

    Sammanfattning : Natural ventilation is the dominating ventilation process in ancient buildings like churches, and also in most domestic buildings in Sweden and in the rest of the world. These buildings are naturally ventilated via air infiltration and airing. LÄS MER

  7. 5. Genetic and epidemiological studies of dystocia : difficult labour

    Författare :Michael Algovik; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Dystocia; epidemiology; genetics; labour; obstetric complications; parturition; susceptibility; uterus;

    Sammanfattning : Objective: To explore the epidemiological characteristics, the influence on reproductive health and the genetic basis of dystocia prolonged and difficult labour. Material and methods: The thesis has a retrospective design and is mainly based on a material from an entire cohort of women, extracted from the Swedish Medical Birth Register, who had their first delivery during the years 1973 to 1997. LÄS MER