Sökning: "NOTCH1"
Visar resultat 1 - 5 av 41 avhandlingar innehållade ordet NOTCH1.
1. Genetic Alterations in Lymphoma : with Focus on the Ikaros, NOTCH1 and BCL11B Genes
Sammanfattning : Cell proliferation is a process that is strictly regulated by a large number of proteins. An alteration in one of the encoding genes inserts an error into the regulative protein, which may result in uncontrolled cell growth and eventually tumor formation. LÄS MER
2. Aniridia-related keratopathy : structural changes, signaling pathways and clinical aspects
Sammanfattning : Aniridia is a congenital autosomal dominant, bilateral, panocular condition, caused by haploinsufficiency of the Pax6 transcription factor. Aniridia-related keratopathy (ARK) significantly affects vision and quality of life in these patients. LÄS MER
3. HIF-dependent Signaling Pathways in Cancer
Sammanfattning : The cellular response to hypoxia, primarily orchestrated by hypoxia-inducible factors (HIFs; mainly HIF-1α and HIF-2α), is at the center of several signaling pathways conferring aggressive tumor behavior. HIFs may be crucially involved in tumor initiation, as seen in clear cell renal cell carcinoma, as well as maintenance of resistance cancer stem cell phenotypes, as observed in glioma. LÄS MER
4. Pancreatic Endocrine Tumourigenesis : Genes of potential importance
Sammanfattning : Understanding signalling pathways that control pancreatic endocrine tumour (PET) development and proliferation may reveal novel targets for therapeutic intervention. The pathogenesis for sporadic and hereditary PETs, apart from mutations of the MEN1 and VHL tumour suppressor genes, is still elusive. LÄS MER
5. Intratumoral heterogeneity in glioblastoma: subtype transition and cell-to-cell communication
Sammanfattning : Glioblastoma is a most aggressive brain tumor with a median overall survival of less than two years. The current treatment is surgery, chemotherapy, and radiotherapy. However, glioblastoma is difficult to treat and recurs some time after treatment. LÄS MER