Sökning: "NOD mice"

Visar resultat 16 - 20 av 59 avhandlingar innehållade orden NOD mice.

  1. 16. Molecular and cellular mechanisms contributing to the pathogenesis of autoimmune diabetes

    Författare :Nádia Duarte; Dan Holmberg; David Serreze; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; type 1 diabetes; NOD mouse; susceptibility loci; Idd6; Lrmp; gene; NKT; CD1d; TCR; mast cells; Immunologi; Immunology; Immunologi; medicinsk genetik; Medical Genetics;

    Sammanfattning : Type 1 diabetes is an autoimmune disorder determined both by genetic and environmental factors. The Non-obese diabetic (NOD) mouse is one of the best animal models of this disease. It spontaneously develops diabetes through a process resembling the human pathogenesis. LÄS MER

  3. 17. Somatostatin Receptor Expression and Biological Functions in Endocrine Pancreatic Cells

    Författare :Eva Ludvigsen; Stellan Sandler; Eva Tiensuu Janson; Mats Stridsberg; Frank Sundler; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell biology; somatostatin; somatostatin receptors; somatostatin analogues; NOD mouse; type 1 diabetes; pancreatic islets; BON-1 cells; Cellbiologi; Cell biology; Cellbiologi;

    Sammanfattning : Type 1 diabetes is resulting from the selective destruction of insulin-producing beta-cells within the pancreatic islets. Somatostatin acts as an inhibitor of hormone secretion through specific receptors (sst1-5). LÄS MER

  4. 18. Dissecting the role of micro-RNAs in diabetes

    Författare :Caroline Bolmeson; Create Health; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Type 1 diabetes; Type 2 diabetes; micro-RNA; Dicer; beta-cell function; insulin secretion; glucose; NOD mouse; Goto-Kakizaki rat; human islets; thymocytes; apoptosis;

    Sammanfattning : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. LÄS MER

  5. 19. NK cell recognition : adaptability to host factors in normal and diabetic mice

    Författare :Sofia Johansson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Natural Killer; NK cell; education; Non obese diabetic; NOD; diabetes; activation; graft; rejection; in vivo; method; receptor; repertoire;

    Sammanfattning : The overall aim of this thesis was to understand the rules, which guide NK cell behavior in vivo. NK cells are part of the innate immune system and are important in defense against certain virus infections and tumorigenic cells. They also play a role in rejecting bone marrow grafts. LÄS MER

  7. 20. Finding genes controlling arthritis in mice-Fcγ receptors and complement C5

    Författare :Dorota Klaczkowska; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Autoimmune diseases are dependent on multifactorial factors including genes, environment and interactions between them. This thesis is focused on a chronic inflammatory disorder, Rheumatoid arthritis (RA). So far only very few genes and environmental factors have been identified reflecting the complexity of the autoimmune processes. LÄS MER