Sökning: "NO-donors"

Visar resultat 1 - 5 av 19 avhandlingar innehållade ordet NO-donors.

  1. 1. Advances in Pharmacological Treatment of Cystic Fibrosis

    Författare :Igor Oliynyk; Godfried M. Roomans; Marie Johannesson; Hugo R. de Jonge; Örebro universitet; []
    Nyckelord :Cystic fibrosis; CFTR; chloride transport; N-acetylcysteine; NO-donors; duramycin; intracellular calcium; azithromycin; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Cystic fibrosis (CF) is an inborn, hereditary disease, due to mutations in the gene for a cAMP-activated chloride (Cl-) channel, the cystic fibrosis transmembrane conductance regulator (CFTR). As a result of impaired ion and water transport,the airway mucus is abnormally viscous, which leads to bacterial colonization. LÄS MER

  3. 2. Nitric oxide generation from nitroglycerin and other no-donors measured in the lung and studies on nitrate tolerance in the cardiovascular system

    Författare :Per Agvald; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Exhaled; nitric oxide; nitroglycerin; nitrite; temperature; tolerance; hypoxia;

    Sammanfattning : Nitroglycerin (GTN) and compounds referred to as nitrovasodilators or NOdonors are frequently used in the treatment of ischemic heart disease. The common mode of action for these drugs is liberation of nitric oxide (NO). Nitric oxide evokes relaxation of smooth muscle through activation of guanylate cyclase with subsequent formation of eGMP. LÄS MER

  4. 3. Experimental skin flaps and nitric oxide

    Författare :Örjan Gribbe; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Surgical flaps; nitric oxide; ischemia; reperfusion; nitrite; laser Doppler; transit-time ultrasound flowmetry; electron microscopy; NO donors; NOS inhibitors;

    Sammanfattning : Surgical flaps are used in plastic surgery to reconstruct tissue defects due to trauma or cancer removal. Occasionally flaps are subjected to ischemia and reperfusion injury leading to flap failure. LÄS MER

  5. 4. The cellular processing of the endocannabinoid anandamide and its pharmacological manipulation

    Författare :Lina Thors; Christopher J Fowler; David A Kendall; Umeå universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Endocannabinoid; anandamide; cellular processing; pain; flavonoids; fatty acid amide hydrolase; Pharmacology; Farmakologi; medicinsk farmakologi; Medical Pharmacology;

    Sammanfattning : Anandamide (arachidonoyl ethanolamide, AEA) and 2-arachidonoyl glycerol (2-AG) exert most of their actions by binding to cannabinoid receptors. The effects of the endocannabinoids are short-lived due to rapid cellular accumulation and metabolism, for AEA, primarily by the enzymes fatty acid amide hydrolase (FAAH). LÄS MER

  7. 5. Nitric oxide and eicosanoids : significance and interactions during antigen-induced responses in peripheral lung tissue

    Författare :Anna-Karin Larsson; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nitric oxide; leukotrienes; prostaglandins; histamine; ovalbumin; contractions; distal lung; rat; human; guinea pig; precision-cut lung slices; mast cell;

    Sammanfattning : Asthma means difficulty in breathing and is described as a chronic, inflammatory disorder that produces narrowing of the lower respiratory tract. The allergen-induced asthmatic bronchoconstriction is primarily caused by an IgE-mediated release of the mast cell mediators, histamine and eicosanoids (leukotrienes and prostanoids). LÄS MER