Sökning: "NHEJ"

Visar resultat 21 - 25 av 25 avhandlingar innehållade ordet NHEJ.

  1. 21. Involvement of Homologous Recombination in Response to Different Qualities of DNA Damage

    Författare :Gunilla Olsson; Mats Harms-Ringdahl; John Thacker; Stockholms universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Toxicology; Toxikologi;

    Sammanfattning : The present studies aimed at elucidate the role of homologous recombination (HR) for the repair of different qualities of DNA damages and/or changes in chromatin structure induced by a variety of radiation qualities.Radiation qualities used to expose cells in culture ranged from non-ionizing radiation with extremely low frequency (ELF), of energies too low to disrupt chemical or molecular bonds, to radiation qualities with energies able to induce ionizations and break chemical bonds. LÄS MER

  3. 22. WRAP53β and scaRNA2 on their journey to repair the DNA

    Författare :Christos Coucoravas; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : WRAP53β is a multifunctional protein involved in several cellular processes like Cajal body formation, telomere maintenance and DNA repair. WRAP53β is responsible for targeting factors to specific cellular locations, and its very high affinity for the scaRNAs could implicate these molecules in similar biological functions. LÄS MER

  4. 23. Targeting MTHFD1 and MTHFD2 as cancer treatment

    Författare :Petra Marttila; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : One-carbon (1C) metabolism provides building blocks for nucleotide synthesis and therefore plays a central role in DNA replication and repair. To sustain rapid proliferation, cancer cells often upregulate their 1C metabolism, including the enzymes MTHFD1 and MTHFD2, as a part of their metabolic rewiring. LÄS MER

  5. 24. Modelling and calculation of DNA damage and repair in mammalian cells induced by ionizing radiation of different quality

    Författare :Reza Taleei; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Recent experimental data have revealed a wealth of information that provides an exceptional opportunity to construct a mechanistic model of DNA repair. The cellular response to radiation exposure starts with repair of DNA damage and cell signalling that may lead to mutation, or cell death. LÄS MER

  7. 25. Analysis and characterization of chemo- and radiation therapy sensitizing strategies in tumours with focus on effects of phenothiazines on DNA damage response signalling

    Författare :Katarzyna Zielinska-Chomej; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Cancer is, despite rapid progress in development of new targeted therapies, still mainly treated with surgery, chemotherapy and/or radiation therapy. The last two mentioned conventional therapies often meet general obstacles such as normal cell toxicity and tumour cell resistance. LÄS MER