Sökning: "NHEJ"

Visar resultat 11 - 15 av 25 avhandlingar innehållade ordet NHEJ.

  1. 11. Study of the mechanisms behind the additive effect of neoadjuvant castration on radiotherapy for prostate cancer

    Författare :Firas L Tarish; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Castration improves responses to radiotherapy (RT) in prostate cancer with unknown mechanism. An understanding of what happens at the cellular and molecular level in prostate cancer cells, while reducing their access to androgens and then exposing them to ionizing radiation (IR), would give us an opportunity to optimize the treatment and may also inspire novel therapeutic approaches. LÄS MER

  3. 12. DNA double-strand break repair in ascomycetes

    Författare :Jiang Chen; Stefan Åström; Michael Lisby; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; utvecklingsbiologi; Developmental Biology;

    Sammanfattning : Nonhomologous end joining (NHEJ) and homologous recombination (HR) are two pathways for DNA double strand break (DSB) repair. We found that the NHEJ protein Nej1 interacted physically with the HR protein Srs2, which was dependent on phosphorylation of Nej1 by Dun1. Srs2 recruitment to a DSB partly relied on Nej1 and Dun1. LÄS MER

  4. 13. Role of DNA repair in class switch recombination and somatic hypermutation

    Författare :Likun Du; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Class switch recombination (CSR) and somatic hypermutation (SHM), occurring in the germinal center, are two important processes for B cell development. Both are initiated by activation-induced cytidine deaminase (AID), through deamination of the C residues in the variable and switch regions of the immunoglobulin locus, resulting in either in single stranded or double stranded DNA breaks. LÄS MER

  5. 14. Characterization of chromatin mobility upon DNA damage in Arabidopsis thaliana

    Författare :Anis Meschichi; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Sammanfattning : Plant cells are subject to high levels of DNA damage from dependence on sunlight for energy and the associated exposure to biotic and abiotic stresses. Double-strand breaks (DSBs) are a particularly deleterious type of DNA damage, potentially leading to chromosome rearrangements or loss of entire chromosome arms. LÄS MER

  7. 15. Unwrapping the role of WRAP53β in DNA damage response

    Författare :Hanif Rassoolzadeh; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : WRAP53β is a WD40 domain protein with multifaceted capabilities in several biological processes in different cellular compartments. This includes transportation of the Survival of motor neuron (SMN) complex, small Cajal body-specific (sca) RNAs and the telomerase enzyme to Cajal bodies, as well as targeting of the E3 ligase RNF8 to DNA double-strand breaks (DSBs). LÄS MER