Sökning: "NG108-15"

Hittade 5 avhandlingar innehållade ordet NG108-15.

1. 1. The effects of growth hormone on opioid-induced toxicity in vitro

   Författare :Erik Nylander; Mathias Hallberg; Alexis Bailey; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Growth hormone; opioids; methadone; morphine; ketobemidone; fentanyl; oxycodone; hydromorphone; insulin-like growth factor; cell viability; NG108-15; SH-SY5Y; hippocampus; cortex; Farmaceutisk vetenskap; Pharmaceutical Science;

   Sammanfattning : There is an ongoing opioid crisis in the United States that is portrayed by a large number of opioid-related deaths. Many of these cases involve commonly used prescription opioids, such as morphine, oxycodone, fentanyl, and methadone. This is concerning and highlights the problems associated with long-term opioid treatment. LÄS MER

3. 2. Molecular mechanisms regulating exocytosis : studies of insulin secretion and neurotransmitter release

   Författare :Lena Lilja; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Cdk5; cell line; DARPP-32; dephosphorylation; exocytosis; inhibitor-1; insulin; islet; kinase; munc18; myotube; p35; p39; phosphatase; phosphorylation; PP1; presynaptic mechanisms; secretion; subcellular localization.;

   Sammanfattning : In order to achieve normal physiology the secretion of hormones and neurotransmitters needs to be firmly controlled. The basic molecular machinery mediating regulated exocytosis of hormones and neurotransmitters is in principal revealed, but knowledge about how the individual components are spatially and temporarily coordinated is limited. LÄS MER

4. 3. Nerve gap repair by the use of artificial conduits and cultured cells

   Författare :Daniel Kalbermatten; Mikael Wiberg; Ulrich Mennen; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adipose stem cells; cell matrix; fibrin; nerve conduit; nerve gap; Surgery; Kirurgi; kirurgi; Surgery;

   Sammanfattning : Peripheral nerve injuries are often associated with loss of nerve tissue and require autologous nerve grafts to provide a physical substrate for axonal growth. This thesis investigates the use of fibrin as both a tubular conduit to guide nerve regeneration and also as a matrix material to suspend various regenerative cell types within/on poly-3-hydroxybutyrate (PHB) nerve conduits. LÄS MER

5. 4. SNAP-25 and Cdk5 as exocytotic regulators : consequences for synaptic function and insulin release

   Författare :Jenny Johansson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : The process by which cells release substances through fusion of vesicles with the plasma membrane is called exocytosis. Regulated exocytosis needs to be tightly controlled in order to respond to the large variation in stimuli and demands for release of neurotransmitters, peptides and hormones. LÄS MER

7. 5. Neurosteroids Induce Allosteric Effects on the NMDA Receptor : Nanomolar Concentrations of Neurosteroids Exert Non-Genomic Effects on the NMDA Receptor Complex

   Författare :Tobias Johansson; Fred Nyberg; Pierre Le Grevès; Elisabeth Hansson; Uppsala universitet; []
   Nyckelord :Pharmaceutical pharmacology; Pharmacology; neurosteroids; NMDA receptor; NR2B subunit; ifenprodil; sigma receptor; anabolic androgenic steroids; allosteric modulation; non-genomic; Farmaceutisk farmakologi;

   Sammanfattning : The neurosteroids constitute a group of powerful hormones synthesized and acting in the central nervous system. They participate in a number of important central processes, such as memory and learning, mood and neuroprotection. LÄS MER