Sökning: "NF-1"

Hittade 5 avhandlingar innehållade ordet NF-1.

  1. 1. The Carboxyl Ester Lipase Gene. Organization, Evolution and Transcriptional Regulation in Exocrine Pancreas and Mammary Gland

    Författare :Ulf Lidberg; Chalmers University of Technology; []
    Nyckelord :NF-1; pseudogene; evolution; pancreas; carboxyl ester lipase; regulation; duplication; promoter; enhancer; locus; gene structure; mammary gland;

    Sammanfattning : The carboxyl ester lipase (CEL) is an important enzyme for the intestinal absorption of dietary lipids. In humans the gene is highly expressed in exocrine pancreas and in the lactating mammary gland. It is secreted in an inactive form and becomes activated by bile salts in the intestine. LÄS MER

  2. 2. Studies on nuclear factor 1 binding to nucleosomal DNA

    Författare :Patrik Blomquist; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; nuclear factor 1; nucleosome; glucocorticoid receptor; triplex DNA; the SWISNF complex; A-tracts; MMTV LTR;

    Sammanfattning : The organisation of DNA into chromatin will influence on transcriptional regulation.The first event in transcriptional activation is the binding of transcription factorsto specific binding sites in the regulatory regions of the gene. LÄS MER

  3. 3. GaN HEMT Low Noise Amplifiers for Radio Base Station Receivers

    Författare :Pirooz Chehrenegar; Chalmers University of Technology; []
    Nyckelord :gallium nitride GaN ; radio base station receiver; cascode; high linearity; robustness.; cascade; high electron mobility transistor HEMT ; low noise; low noise amplifier;

    Sammanfattning : Gallium nitride (GaN) high electron mobility transistor (HEMT) has been introduced as the technology of choice for high power microwave applications due to its material properties including high saturation electron velocity and breakdown field together with excellent thermal conductivity and robustness.It is also a promising candidate for receiver front-ends in the radio base station(RBS) where low noise figure and high linearity are key issues for low noiseamplifier (LNA) design. LÄS MER

  4. 4. Studies on growth hormone induced female-characteristic gene transcription in rat liver

    Författare :Cissi Gardmo; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Growth hormone; liver; gene expression; sex differentiation; in vivo transfection; primary hepatocytes;

    Sammanfattning : Growth hormone (GH) secretion is sexually dimorphic, which has an impact on hepatic gene expression. This is particularly pronounced in rats but has also been demonstrated in other species, including humans. LÄS MER

  5. 5. Studies on the transcriptional regulation of sterol 12alpha-hydroxylase (CYP8B1)

    Författare :Yizeng Yang; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; Bile acids; CYP8B1; CYP7A1; transcription; nuclear receptor; PPAR-alpha; HNF4-alpha; FTF; SREBP; thyroid hormones.;

    Sammanfattning : The conversion of cholesterol into bile acids is mainly via two pathways, which are initiated by CYP7A1 and CYP27A1 respectedly. CYP8B1, a microsomal P450 cytochrome, hydroxylates of the steroid nucleus at the C-12alpha position to form 7alpha, 12alpha-dihydroxy-4-cholesten-3-one, a facultative precursor of CA. LÄS MER