Sökning: "NEUROGENESIS"

Visar resultat 1 - 5 av 169 avhandlingar innehållade ordet NEUROGENESIS.

  1. 1. Regeneration in the adult brain after focal cerebral ischemia : exploration of neurogenesis and angiogenesis

    Författare :Wei Jiang; Jukka Jolkkonen; Umeå universitet; []
    Nyckelord :LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES; neurogenesis; angiogenesis; rats; mice; gliosis; BrdU; CBF; protein synthesis; ATP; penumbra; reperfusion; VEGF; 3-D confocal; photothrombosis; MCAO; Medicine; Medicin;

    Sammanfattning : Background: Ischemic stroke ranks as the third major cause of clinical mortality and the leading cause of handicap in adults. Each year, stroke occurs in about 30,000 Swedes. The severity of an acute ischemic stroke depends mainly on the degree and duration of local cerebral blood flow (lCBF) reduction. LÄS MER

  3. 2. Neurogenesis and transplantation in stroke-damaged brain

    Författare :Vladimer Darsalia; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neuropsychology; neurophysiology; Neurologi; Neurology; Stroke; Transplantation; Stem cells; Aging; Neurogenesis; neurofysiologi;

    Sammanfattning : Stroke in young adult rodents triggers neurogenesis in the damaged striatum and intact hippocampus. as stroke happens frequently in aged individuals it is of great importance to know whether aging affects brain recovery mechanisms. LÄS MER

  4. 3. Death mechanisms compromising hippocampal neurogenesis after status epilepticus

    Författare :Christine Ekdahl Clementson; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi; minocycline; lipopolysaccharide; microglia activation; status epilepticus; epilepsy; cysteinyl aspartate-specific proteases; apoptosis; neurogenesis; progenitor cell progeny;

    Sammanfattning : Status epilepticus (SE) leads to neurodegeneration as well as neurogenesis in the adult rat hippocampus. This thesis demonstrates that even if the neurogenic response initially is very pronounced, with a several-fold increase in cell proliferation, the survival of the newly formed neurons is compromised by a death mechanism involving mitochondria-related caspases. LÄS MER

  5. 4. Brain Inflammation and Adult Hippocampal Neurogenesis in Epilepsy

    Författare :Deepti Chugh; Lund Neurologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Epilepsy; Inflammation; Neurogenesis; Hippocampus; Microglia; Adhesion molecules; Scaffolding proteins;

    Sammanfattning : Epilepsy is a severe chronic neurological disorder characterized by recurrent spontaneous seizures. Excitatory/inhibitory (E/I) imbalance, neuronal loss, brain inflammation, and altered adult neurogenesis are some of the characteristic hallmarks of epilepsy. LÄS MER

  7. 5. Neurogenesis in the adult brain from ballyhoo to sobriety

    Författare :Helena Frielingsdorf; Institutionen för experimentell medicinsk vetenskap; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neuropsykologi; neurofysiologi; Neurologi; neurophysiology; neuropsychology; Neurology; Nerve growth factor; acetylcholine; GABA; learning; hippocampus; Neurogenesis; dopamine; substantia nigra;

    Sammanfattning : New neurons are spontaneously generated in two regions of the adult brain, the hippocampus and the subventricular zone/olfactory bulb. The objective of this thesis was to study potential implications for adult neurogenesis in Alzheimer's (AD) and Parkinson's diseases (PD). LÄS MER