Sökning: "NDST1"

Visar resultat 6 - 9 av 9 avhandlingar innehållade ordet NDST1.

1. 6. Heparan Sulfate Biosynthesis – Clues from Knockout Mice

   Författare :Johan Ledin; Lena Kjellén; John Gallagher; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; heparan sulfate; biosynthesis; gene targeting; embryonic development; proteoglycans; NDST; N-deacetylase N-sulfotransferase; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : In the extracellular space, many specialized proteins are located to support cells and to mediate cell-cell signalling. One class of such molecules is heparan sulfate (HS) proteoglycans, which are proteins with different properties and locations but all of them decorated with long unbranched HS polysaccharide chains. LÄS MER

3. 7. Cellular design of heparan sulfate : The NDST enzymes and their regulation

   Författare :Pernilla Carlsson; Lena Kjellén; Tarja Kinnunen; Uppsala universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; heparan sulfate; heparin; proteoglycan; NDST; PAPS; Golgi; Cell and molecular biology; Cell- och molekylärbiologi;

   Sammanfattning : Heparan sulfate proteoglycans are proteins with long, unbranched heparan sulfate (HS) polysaccharide chains attached to them. They are found on cell surfaces and in basement membranes where they exert their action by interacting with a wide range of enzymes and signaling molecules and are thereby involved in a range of various processes both during embryonic development and in adult physiology. LÄS MER

4. 8. Myofibroblasts and the Vascular Endothelium : Impact of Fibrin Degradation Products and miRNA on Vascular Motility and Function

   Författare :Peder Fredlund Fuchs; Pär Gerwins; Johan Kreuger; Arne Östman; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Angiogenesis; Vascular biology; Chemotaxis; Endothelial cell; Myofibroblast; Wound healing; miRNA; Heparan sulfate; Medical Science; Medicinsk vetenskap;

   Sammanfattning : Angiogenesis is the formation of new blood vessels from pre-existing vasculature and is important during development as well as wound healing and tissue remodeling. Angiogenesis also occurs during pathological conditions such as diabetic retinopathy and cancer. LÄS MER

5. 9. Vascular development : from embryonic stem cells to arteries and veins

   Författare :Fredrik Lanner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : A fundamental question in developmental biology is how a single fertilized egg cell and its progeny are programmed or instructed to form thousands of different cell types and how these are organized into a complex and functional organism. In this thesis I have explored how a specific subset of cells is formed - the vascular endothelial cells lining our blood vessels. LÄS MER