Sökning: "NATURVETENSKAP Kemi Molekylär biofysik"

Visar resultat 1 - 5 av 11 avhandlingar innehållade orden NATURVETENSKAP Kemi Molekylär biofysik.

  1. 1. Tunable and modular assembly of polypeptides and polypeptide-hybrid biomaterials

    Författare :Christopher Aronsson; Daniel Aili; Karin Enander; Staffan Dånmark; Dennis Löwik; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Biomaterials are materials that are specifically designed to be in contact with biological systems and have for a long time been used in medicine. Examples of biomaterials range from sophisticated prostheses used for replacing outworn body parts to ordinary contact lenses. Currently it is possible to create biomaterials that can e.g. LÄS MER

  2. 2. Peptide-Liposome Model Systems for Triggered Release

    Författare :Camilla Skyttner; Daniel Aili; Karin Enander; Fredrik Höök; Linköpings universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Liposomes are widely used in drug delivery to improve drug efficacy and to reduce side effects. For liposome-encapsulated drugs to become bioavailable and provide a therapeutic effect they must be released, which typically is a slow process that primarily relies on passive diffusion, liposome rupture or endocytotic uptake. LÄS MER

  3. 3. NMR STUDIES ON STRUCTURE AND DYNAMICS OF TWO-DOMAIN PROTEINS

    Författare :Houman Ghasriani; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Fysikalisk kemi; Biochemistry; Metabolism; Biokemi; metabolism; Physical chemistry; Molekylär biofysik; CRISP-3; NMR; 3D-structure; NMR relaxation; Molecular biophysics; Prostate cancer; EGF module; PSP94; Beta-microseminoprotein; Protein S;

    Sammanfattning : The general objective of the present thesis work was to examine 3-dimensional structure as well as the motional properties of two different types of two-domain proteins by solution-state NMR. One of the major tasks of this thesis work was to investigate the domain orientation of these molecules by employing residual dipolar couplings (RDC) which can be used as orientational restraints for increasing the accuracy of protein structures determined by NMR. LÄS MER

  4. 4. Protein Interactions: Electrostatics and Ligand Binding

    Författare :Ingemar André; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molecular biophysics; Molekylär biofysik; secondary structure formation; protein GB1; pKa values; pH stability; NMR; electrostatic interactions; M proteins; calbindin D9k; calcium binding; cooperativity; calmodulin; calbindin D28k;

    Sammanfattning : This thesis deals with Ca2+ binding to proteins, electrostatic interactions in and between proteins as well as inter- and intramolecular interactions. A computer program was developed to determine Ca2+ binding constants from experimental titration data of proteins. LÄS MER

  5. 5. Protein Dynamics Studied by NMR Spin Relaxation. Conformational Transitions of a Calmodulin Mutant

    Författare :Patrik Lundström; Biofysikalisk kemi; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Molekylär biofysik; Molecular biophysics; spin relaxation; rotating-frame; NMR; multiple-quantum; EF-hand; chemical shift; chemical exchange; calcium binding proteins; calmodulin;

    Sammanfattning : Binding of calcium to the protein calmodulin leads to molecular reorganization that enables interaction with target peptides and activation of downstream processes. I have studied the dynamics of the calcium-loaded form of a C-terminal calmodulin mutant (E140Q-Tr2C) using NMR spin relaxation experiments. LÄS MER