Sökning: "NATURVETENSKAP Biologi Cell- och molekylärbiologi Immunologi"

Visar resultat 21 - 25 av 45 avhandlingar innehållade orden NATURVETENSKAP Biologi Cell- och molekylärbiologi Immunologi.

  1. 21. Regulation of Gene Expression in Multiple Myeloma Cells and Normal Fibroblasts : Integrative Bioinformatic and Experimental Approaches

    Författare :Prasoon Agarwal; Helena Jernberg Wiklund; Håkan Axelson; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Multiple myeloma; Integrative bioinformatics; Epigenetics; CGGBP1; RNA polymerase; Oncology; Onkologi; Bioinformatik; Bioinformatics;

    Sammanfattning : The work presented in this thesis applies integrative genomic and experimental approaches to investigate mechanisms involved in regulation of gene expression in the context of disease and normal cell biology.In papers I and II, we have explored the role of epigenetic regulation of gene expression in multiple myeloma (MM). LÄS MER

  3. 22. Molecular characterization of the Drosophila responses towards nematodes

    Författare :Md. Badrul Arefin; Ulrich Theopold; Ioannis Eleftherianos; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Drosophila; nematodes; infection; danger situations; immune response; coagulation; apoptosis; nitric oxide; leukemia; Molecular Biology; molekylärbiologi;

    Sammanfattning : A sophisticated evolutionary conserved innate immune system has evolved in insects to fight pathogens and to restrict damage in harmful (danger) situations including cancer. A significant amount of knowledge about different infection models in Drosophila has been generated in past decades, which revealed functional resemblances and implications for vertebrate systems. LÄS MER

  4. 23. Induction of Mast Cell Apoptosis via Granule Permeabilization : A Novel Approach to Target Mast Cells

    Författare :Aida Paivandy; Gunnar Pejler; Magda Babina; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mast cells; Granules; Apoptosis; Reactive oxygen species; ROS; Lysosomotropic agents; Mefloquine; Immunologi; Immunology; Biokemi; Biochemistry;

    Sammanfattning : Mast cells are densely granulated tissue-resident immune cells that play an important role in orchestrating inflammatory responses. Dysregulated increases in the numbers and activation status of mast cells can have deleterious consequences for the body in various inflammatory diseases. LÄS MER

  5. 24. Deradicalising Giardiasis Treatment

    Författare :Sascha Krakovka; Staffan Svärd; Jon Jerlström-Hultqvist; Norbert Müller; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Giardia; encystation; antibiotic resistance; metronidazole; transcriptomics; proteomics; thymidine kinase;

    Sammanfattning : Giardia intestinalis is a unicellular parasite causing the disease giardiasis. This disease is mostly prevalent in low resource settings, mandating low-cost treatment options. LÄS MER

  7. 25. Functional study of hemolymph coagulation in Drosophila larvae

    Författare :Zhi Wang; Ulrich Theopold; Brian Lazzaro; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; innate immunity; hemolymph coagulation; clot components; Drosophila larvae; Molecular Biology; molekylärbiologi;

    Sammanfattning : Many pathogen infections in nature are accompanied by injury and subsequent coagulation. Despite the contribution of hemolymph coagulation to wound sealing, little is known about its immune function. LÄS MER