Sökning: "NATURAL SCIENCES Chemistry Theoretical chemistry Bioinformatics"
Visar resultat 11 - 14 av 14 avhandlingar innehållade orden NATURAL SCIENCES Chemistry Theoretical chemistry Bioinformatics.
11. The relationship between orthology, protein domain architecture and protein function
Sammanfattning : Lacking experimental data, protein function is often predicted from evolutionary and protein structure theory. Under the 'domain grammar' hypothesis the function of a protein follows from the domains it encodes. LÄS MER
12. Biological data exchange and the discovery of new protein families in metagenomic samples
Sammanfattning : The rise in sequence data has brought both challenges to the way we exchange biological information and opportunities to discover new protein families, primarily through the investigation of uncultured metagenomic samples.The Distributed Annotation System, or DAS, provided a means for exchanging protein sequence data, but there were no open source, stand-alone DAS clients optimized for integrating and viewing these data. LÄS MER
13. Inference of functional association networks and gene orthology
Sammanfattning : Most proteomics and genomics experiments are performed on a small set of well-studied model organisms and their results are generalized to other species. This is possible because all species are evolutionarily related. When transferring information across species, orthologs are the most likely candidates for functional equivalence. LÄS MER
14. Data integration for robust network-based disease gene prediction
Sammanfattning : For many complex diseases the cause/mechanism can be tied not to a single gene and in order to cope with the complexity a systems wide approach is needed. By combining evidence indicative of functional association it is possible to infer networks of protein functional coupling. LÄS MER