Sökning: "NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry"

Visar resultat 6 - 10 av 40 avhandlingar innehållade orden NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry.

  1. 6. C1 Building Blocks: New Approaches for Thiomethylations and Esterification

    Författare :Marcus Söderström; Luke R. Odell; Anders Karlén; Vittorio Pace; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Borontrifluoride; Dimethylsulfide; Thiomethylation; Methylthioethers; Dithioacetalation; Methyl-Dithioacetals; Friedel-Crafts; Diarylmethanes; Defluorination; Methyl-Dithioesters; Thioamides; Diazomethane; Esterification; Medicinal Chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Sammanfattning : The thioether motif is found in numerous pharmaceuticals. The simplest form of this motif, the methyl-thioether is similarly found in many biologically active compounds and has exhibited many advantageous properties. The installation of the thiomethyl moiety can be troublesome due to the toxicity and malodor of small sulfur reagents. LÄS MER

  3. 7. Design and Synthesis of 11C-Labelled Compound Libraries for the Molecular Imaging of EGFr, VEGFr-2, AT1 and AT2 Receptors : Transition-Metal Mediated Carbonylations Using [11C]Carbon Monoxide

    Författare :Ola Åberg; Bengt Långström; Nicholas Long; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; [11C]carbon monoxide; isotopic labelling; PET; acrylamide; EGFR; VEGFR-2; 11C; Organic chemistry; Organisk kemi; Organic Chemistry; Organisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Sammanfattning : This work deals with radiochemistry and new approaches to develop novel PET tracers labelled with the radionuclide 11C.Two methods for the synthesis of 11C-labelled acrylamides have been explored. LÄS MER

  4. 8. Design, Synthesis and Thermodynamic Studies of Galectin Ligands

    Författare :Maria Luisa Verteramo; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; galectin; conformational entropy; solvation; thermodynamic; interaction; molecular recognition; thiodigalactoside; diastereomer; structure-based design;

    Sammanfattning : The signaling within and between cells in biology is governed by molecular recognition between natural or synthetic ligands and proteins. This thesis project aimed to investigate the thermodynamic properties of specific interaction between synthetic ligands and galectin proteins. LÄS MER

  5. 9. Synthesis of Spiro-bicyclo[2.2.2]Octane Derivatives Towards the Development of Paclitaxel Mimetics

    Författare :Viveca Thornqvist; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Kemi; Organic chemistry; Organisk kemi; Chemistry; Natural science; paclitaxel; spiro; indium; Naturvetenskap; bicyclo[2.2.2]octane; allylation; paclitaxel mimetic;

    Sammanfattning : Many of the drugs that are developed in the pharmaceutical industry have their origin in natural products. Paclitaxel, the active substance of the medicine Taxol, was found in the bark of the Pacific yew tree (Taxus brevifolia). LÄS MER

  7. 10. Biologically Interesting Compounds from Natural Sources

    Författare :Veronica de la Parra; Centrum för analys och syntes; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; cytotoxicity; Natural products; terpenoids; vasorelaxant activity; allylmercaptane; diabetes mellitus type II; Organisk kemi; Organic chemistry; Cacalia decomposita; GPR40 receptor; TRP channel;

    Sammanfattning : Natural products have traditionally played a major role in the drug discovery process. Besides constituting extremely popular drugs in the market, and an ever-increasing source of interesting and novel chemical structures, they have also aided the characterization of many a pharmacological target. LÄS MER