Sökning: "NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry"
Visar resultat 16 - 20 av 40 avhandlingar innehållade orden NATURAL SCIENCES Chemistry Organic chemistry Pharmaceutical chemistry.
16. Characterization of Secondary Metabolites from Natural Sources
Sammanfattning : Natural products have contributed for many years to the development of new medicines for the treatment of diseases. Their structural diversity and complexity have inspired chemists to produce interesting compounds with pharmaceutical use. LÄS MER
17. Computational Studies of Transition Metal-Catalyzed Asymmetric Transfer Hydrogenation Reactions
Sammanfattning : This thesis is based on two studies dealing with the computational investigation of asymmetric transfer hydrogenation reactions, in which hydrogen is transferred from a donor molecule (e.g. alcohol) to a substrate (ketone), via mediation of a metal-ligand catalyst complex. LÄS MER
18. Palladium(II)-Catalyzed Oxidative Carbocyclization/Functionalization of Allenynes
Sammanfattning : The selective formation of carbon-carbon bonds constitutes a key transformation in organic synthesis with useful applications in pharmaceutical or material industry. A particularly versatile tool for carbon-carbon as well as carbon-heteroatom bond formation is palladium catalysis, which allows for mild and selective routes even towards complex structures. LÄS MER
19. Experimental Designs at the Crossroads of Drug Discovery
Sammanfattning : New techniques and approaches for organic synthesis, purification and biological testing are enabling pharmaceutical industries to produce and test increasing numbers of compounds every year. Surprisingly, this has not led to more new drugs reaching the market, prompting two questions – why is there not a better correlation between their efforts and output, and can it be improved? One possible way to make the drug discovery process more efficient is to ensure, at an early stage, that the tested compounds are diverse, representative and of high quality. LÄS MER
20. Transition metal-catalyzed allylic and vinylic functionalization : Method development and mechanistic investigations
Sammanfattning : The use of small molecule building blocks in, for example, pharmaceutical research and new material development, creates a need for new and improved organic synthesis methods. The use of transition metals as mediators and catalysts opens up new reaction pathways that have made the synthesis of completely new compounds possible as well as greatly improved the synthetic routes to known compounds. LÄS MER
