Sökning: "NALP3"

Hittade 3 avhandlingar innehållade ordet NALP3.

1. 1. Genetic variations in the NALP3 inflammasome: a susceptibility factor for inflammatory diseases

   Författare :Deepti Verma; Peter Söderkvist; Ulf Andersson; Linköpings universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Inflammasome; Interleukin-1 beta; NALP3; autoinflammation; Medical genetics; Medicinsk genetik;

   Sammanfattning : Innate immunity has received impressive attention in the past decade owing to the discovery of the Toll like receptors (TLRs) and the NOD-like receptors (NLRs). While the TLRs specialize in fighting microbes at the cell surface, the NLRs complement by detecting and responding to intracellular microbes. LÄS MER

3. 2. Mechanisms of bacterial-epithelial interaction in Crohn’s disease

   Författare :Ida Schoultz; Johan D. Söderholm; Nicola Jones; Linköpings universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : Crohn’s disease (CD) is believed to be initiated when an individual, who has agenetic predisposition either leading to a disturbance in the barrier functionand/or the innate immune system is exposed to triggering environmentalfactors, the most important being intraluminal bacteria. Genetic and functionalstudies have confirmed the Pattern-recognition receptors (PRRs), Nod2, TLR4and NALP3, as important mediators of the inflammatory process associatedwith disease progression. LÄS MER

4. 3. Clinical and pathogenic aspects of otitis media

   Författare :Anna Granath; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : One study on clinical treatment strategies in otitis media and two studies elucidating immunological events in otitis media in vitro, were conducted and joined in this thesis. First, topical treatment with or without systemic antibiotics against tube associated otorrhea in children with recurrent acute otitis media was evaluated. LÄS MER