Sökning: "NAC treatment"

Visar resultat 1 - 5 av 41 avhandlingar innehållade orden NAC treatment.

  1. 1. Inflammation and neuroprotective strategies in the immature brain after hypoxic-ischemic brain injury

    Författare :Pernilla Svedin; Göteborgs universitet; []
    Nyckelord :hypoxia-ischemia; LPS; immature; brain; inflammation; NAC; melatonin; G-2mPE; MMP-9; MMP-12;

    Sammanfattning : Perinatal brain injury, as a result of hypoxia-ischemia (HI) or infection/HI, is a major cause of acute mortality and neurological morbidity in infants and children. The mechanisms of perinatal HI are not fully understood, which makes it difficult to find effective treatment. LÄS MER

  3. 2. Teratogenicity Involved in Experimental Diabetic Pregnancy

    Författare :Mattias Gäreskog; Parri Wentzel; Ulf Eriksson; Jonas Cederberg; Kari Teramo; Uppsala universitet; []
    Nyckelord :Cell biology; Diabetes; Pregnancy; PKC; Apoptosis; Rat; Embryopathy; Vitamin E; Folic acid; CHC; NAC; Cellbiologi;

    Sammanfattning : Maternal diabetes is associated with increased risk of growth disturbances and congenital malformations. The malformations rate in the offspring of diabetic mothers is 2-3 fold higher compared to infants of nondiabetic mothers. LÄS MER

  4. 3. Advances in Pharmacological Treatment of Cystic Fibrosis

    Författare :Igor Oliynyk; Godfried M. Roomans; Marie Johannesson; Hugo R. de Jonge; Örebro universitet; []
    Nyckelord :Cystic fibrosis; CFTR; chloride transport; N-acetylcysteine; NO-donors; duramycin; intracellular calcium; azithromycin; MEDICINE; MEDICIN; Medicin; Medicine;

    Sammanfattning : Cystic fibrosis (CF) is an inborn, hereditary disease, due to mutations in the gene for a cAMP-activated chloride (Cl-) channel, the cystic fibrosis transmembrane conductance regulator (CFTR). As a result of impaired ion and water transport,the airway mucus is abnormally viscous, which leads to bacterial colonization. LÄS MER

  5. 4. Novel pharmacological treatment alternatives for nicotine dependence

    Författare :Nina Lindblom; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Nicotine; dependence; withdrawal; reinstatement; smoking; active immunisation; immunoconjugate; vaccine; dopamine stabiliser; - -DS121; dopamine; nucleus accumbens; intra cranial selfstimulation;

    Sammanfattning : Smoking has been identified as the single largest preventable cause of morbidity and premature death in the developed world. Despite the well known health risks associated with smoking the number of smokers are still rising globally. LÄS MER

  7. 5. Experimental studies on novel pharmacological strategies in the treatment of schizophrenia

    Författare :Amani Eltayb; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Schizophrenia; L-dopa; topiramate; 5-HT2C; citalopram; WAY 100635; CAR; catalepsy;

    Sammanfattning : The modified dopamine (DA) hypothesis of schizophrenia suggests a hyperdopaminergic state in subcortical brain regions, which is believed to cause positive symptoms, while cortical regions may show a hypodopaminergic state which is believed to generate negative and cognitive symptoms. Positive symptoms are improved by typical antipsychotic drug (APD) treatment. LÄS MER