Sökning: "NA assembly"

Visar resultat 1 - 5 av 10 avhandlingar innehållade orden NA assembly.

1. 1. Influenza neuraminidase assembly : Evolution of domain cooperativity

   Författare :Diogo da Silveira Vieira da Silva; Robert Daniels; Ron Fouchier; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Influenza; neuraminidase; assembly; transmembrane domain; evolution; Biochemistry; biokemi;

   Sammanfattning : Influenza A virus (IAV) is one of the most common viruses circulating in the human population and is responsible for seasonal epidemics that affect millions of individuals worldwide. The need to develop new drugs and vaccines against IAVs led scientists to study the main IAV surface antigens hemagglutinin (HA) and neuraminidase (NA). LÄS MER

3. 2. NA transmembrane domain : Amphiphilic drift to accommodate two functions

   Författare :Johan Nordholm; Robert Daniels; Ervin Fodor; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; influenza; IAV; neuraminidase; NA; transmembrane domain; TMD; secretory protein; ER-targeting sequence; ER-targeting sequence coding region; protein regulation; NS1; GALLEX; Biochemistry; biokemi;

   Sammanfattning : Neuraminidase (NA) is one of two major antigens on the surface of influenza A viruses. It is comprised of a single N-terminal transmembrane domain (TMD), a stalk domain, and a C-terminal enzymatic head domain that cleaves sialic acid, most notably to release new particles from the host cell surface. LÄS MER

4. 3. Influenza A Virus : Spatial analysis of influenza genome trafficking and the evolution of the neuraminidase protein

   Författare :Dan Dou; Robert Daniels; Martin Schwemmle; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Influenza A virus; IAV; neuraminidase; NA; IAV genome trafficking; viral entry; viral replication; co-infection; antigenic drift; antigenic shift; NA assembly; transmembrane domain; evolution; Biochemistry; biokemi;

   Sammanfattning : Influenza A viruses (IAVs) are a common infectious agent that seasonally circulates within the human population that causes mild to severe acute respiratory infections. The severity of the infection is often related to how the virus has evolved with respect to the pre-existing immunity in the population. LÄS MER

5. 4. Templating and self-assembly of biomimetic materials

   Författare :Christian Mille; Lennart Bergström; Mika Linden; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; biomimetic; biotemplating; self-assembly; triply periodic minimal surfaces; the gyroid; photonic crystals; band gap; structural color; chirality; butterflies; membrane proteins; lipid bilayers; sol-gel; mesostructured; polyhedral nanofoams; Materials Chemistry; materialkemi;

   Sammanfattning : This thesis focuses on the use of biomolecular assemblies for creating materials with novel properties. Several aspects of biomimetic materials have been investigated, from fundamental studies on membrane shaping molecules to the integration of biomolecules with inorganic materials. LÄS MER

7. 5. Filament assembly and structural studies of intermediate filament like protein, FilP, in Streptomyces coelicolor

   Författare :Ala Javadi; Linda Sandblad; Martin Thanbichler; Umeå universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Cytoskeleton; Intermediate filament-like; FilP; Streptomyces coelicolor; filament assembly; cryoelectron tomography; single particle analysis; crystallography; cellulose affinity;

   Sammanfattning : The cytoskeleton, known as intracellular connected filaments, has a prominent role in cellular behavior, motility, and stability. The following three major types of polymers have been characterized as cytoskeleton in eukaryotes: microtubules that are 25 nm in diameter, actin filaments that are 7 nm in diameter, and intermediate filaments (IF) that are 10 nm in diameter. LÄS MER