Sökning: "N-methyl-D-aspartate"

Visar resultat 21 - 25 av 45 avhandlingar innehållade ordet N-methyl-D-aspartate.

1. 21. GABA-, glycine- and glutamate-induced currents in rat medial preoptic neurons : functional interactions and modulation by capsaicin

   Författare :Urban Karlsson; Staffan Johansson; Johannes Krupp; Bryndis Birnir; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; medial preoptic nucleus; synaptic transmission; glutamate; GABA; glycine; TRPV1; Physiology; Fysiologi;

   Sammanfattning : The medial preoptic nucleus (MPN) of the hypothalamus plays a major role in many functions involved in maintaining bodily homeostasis, such as thermoregulation and osmoregulation, as well as in the control of complex behaviours, e.g. sexual behaviour. LÄS MER

3. 22. Movement pattern analysis of hypoglutamatergic mice. A model for cognitive deficits of schizophrenia and autism?

   Författare :Marie Nilsson; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; schizophrenia; autism; cognition; movement pattern; video tracking; MK-801; mice;

   Sammanfattning : Schizophrenia and autism are two severe neuropsychiatric disorders that are associated withprofound cognitive disturbances which considerably contribute to the long-term morbidity andthe decreased ability to function in the society. Currently used therapies do not reach the corecognitive disturbances to a satisfactory extent. LÄS MER

4. 23. Development of in vitro and ex vivo positron-emitting tracer techniques and their application to neurotrauma

   Författare :Sven Sihver; Uppsala universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Neurosciences; Short-lived radionuclides; in vitro receptor binding; in vitro and ex vivo autoradiography; positron emission tomography; benzodiazepine; muscarinic acetylcholine; and NMDA receptors in CNS; experimental neurotrauma; Neurovetenskap; Neurology; Neurologi; medicinsk farmakologi; Medical Pharmacology;

   Sammanfattning : The use of positron-emitting tracers has been extended beyond tomographic facilities in the last few years, giving rise to a general positron-emitting tracing technique. The methodological part of the present thesis involved the evaluation of the performance of storage phosphor (SP) plates, with tracers labeled with high-energy, short-lived, positron-emitting radionuclides, using homogenized tissue specimens and autoradiography with frozen brain sections. LÄS MER

5. 24. Cholecystokinin, dopamine and glutamate in subcortical and peripheral control of food intake

   Författare :Min Qian; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :cholecystokinin; dopamine; glutamate; food intake;

   Sammanfattning : This thesis analyzes some of the mechanisms whereby cholecystokinin octapeptide (CCK-8) inhibits food intake in male rats. Depletion of monoamines using reserpine blocked the capacity for ingestive responses. These responses were restored in reserpinized rats by treatment with the non-competitive N-methyl-D-aspartate receptor antagonist MK-801. LÄS MER

7. 25. Schizophrenia and Nitric Oxide: Deficits in Information Processing Invetigated in Animal Models

   Författare :Daniel Klamer; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; phencyclidine – nitric oxide – prepulse inhibition – habituation – acoustic startle – cAMP – in vivo microdialysis – NMDA receptor – rat – mouse – schizophrenia;

   Sammanfattning : Rationale: Schizophrenia-like symptoms can be induced in humans by phencyclidine (PCP), a non-competitive antagonist of the N-methyl-D-aspartate (NMDA) receptor. Schizophrenic patients and PCP-treated animals display deficits in pre-attentive information processing, as assessed by e.g. prepulse inhibition of the acoustic startle response. LÄS MER