Sökning: "N-glycan"

Visar resultat 6 - 10 av 12 avhandlingar innehållade ordet N-glycan.

  1. 6. HIV-1 envelope protein gp120. Glycovirology of the V3 loop

    Författare :Britt Losman; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; AIDS; HIV-1; Carbohydrates; V3-region; V1-region; Coreceptors;

    Sammanfattning : The human immunodeficiency virus type 1 (HIV-1) infection usually is lethal as a consequence of the acquired immunodeficiency syndrome (AIDS). HIV-1 is an enveloped virus and the trimeric envelope glycoprotein complex, gp120/gp41, is responsible for binding of the virus both to the primary cellular receptor CD4 and the coreceptors, CXCR4 and CCR5. LÄS MER

  3. 7. Multi-dimensional omics approaches to dissect natural immune control mechanisms associated with RNA virus infections

    Författare :Anoop Tholamplackil Ambikan; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : In recent decades, global health has been challenged by emerging and re-emerging viruses such as severe acute respiratory syndrome coronavirus 2 (SARS-CoV2), human immunodeficiency viruses (HIV-1), and Crimean–Congo hemorrhagic fever virus (CCHFV). Studies have shown dysregulations in the host metabolic processes against SARS-CoV2 and HIV-1 infections, and the research on CCHFV infection is still in the infant stage. LÄS MER

  4. 8. Elucidating Genetic and Biochemical Aspects of the P1 and Sda Carbohydrate Histo-Blood Group Antigens

    Författare :Linn Stenfelt; Avdelningen för hematologi och transfusionsmedicin; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Blood Group; P1 antigen; Sda antigen; A4GALT; B3GALNT2; glycosyltransferase; red blood cell; transfusion medicine;

    Sammanfattning : Human histo-blood groups are inherited polymorphic variants that occur in the molecular structures on the humanred blood cell (RBC) surface. Introducing foreign RBCs into a recipient lacking an antigen may activate the humoraldefence leading to a hemolytic transfusion reaction. LÄS MER

  5. 9. Interactions between herpes simplex virus type 1 glycoprotein C and cell surface glycosaminoglycans

    Författare :Kristina Mårdberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Herpes simplex virus-1; glycoprotein C; virus receptor; glycosaminoglycans; heparan sulfate; chondroitin sulfate;

    Sammanfattning : The cell surface glycosaminoglycan (GAG) heparan sulfate (HS) serves as an initial receptor for herpes simplex virus type 1 (HSV-1) and virus attachment to the HS molecule is mediated by the envelope glycoprotein C (gC). In the first part of this thesis, we aimed to define the HS-binding domain of viral gC. LÄS MER

  7. 10. Role of GPIbαlpha Clustering and N-linked Carbohydrates in the Clearance of Refrigerated Platelets

    Författare :Emma Josefsson; Göteborgs universitet; []
    Nyckelord :Platelets; GPIbalpha; alphaMbeta2; phagocytosis; refrigerated platelets;

    Sammanfattning : The thesis focuses on understanding the mechanisms by which: 1) the macrophage alphaM-subunit recognizes betaN-acetylglucosamine (betaGlcNAc) residues on the von Willebrand factor receptor complex ((GPIbalpha,beta/IX)2V or vWfR) on refrigerated platelets and 2) refrigeration changes vWfR to elicit recognition through alphaMbeta2. Until recently, the only well-established mechanisms affecting platelet survival were antibody-mediated platelet clearance, consumption of platelets by coagulation reactions, and loss due to massive bleeding. LÄS MER