Sökning: "Myoglobin"

Visar resultat 1 - 5 av 27 avhandlingar innehållade ordet Myoglobin.

1. 1. Myoglobin : methodological, experimental and clinical studies

   Författare :Lars-Eric Roxin; Uppsala universitet; []
   Nyckelord :MEDICINE; MEDICIN;

   Sammanfattning : .... LÄS MER

3. 2. From Time-Averaged to Time-Resolved Crystallography: Studies on Superoxide Dismutase and Myoglobin

   Författare :Thomas Ursby; Lunds universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; superoxide dismutase; Bayesian statistics; electron difference maps; synchrotron; docking site; photolysis; myoglobin; Time-resolved crystallography; Laue; thermostability; Sulfolobus solfataricus; Molecular biophysics; Molekylär biofysik;

   Sammanfattning : We have studied protein motions with nanosecond time-resolved crystallography. The release of carbon monoxide from its complex with myoglobin (MbCO) was triggered by nanosecond laser pulses. X-ray data were collected with time delays ranging from 4 ns to 1.9 ms using the Laue method, at the European Synchrotron Radiation Facility in Grenoble. LÄS MER

4. 3. Theoretical studies of porphyrin proteins

   Författare :Emma Sigfridsson; Beräkningskemi; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; molecular mechanics; quantum chemical calculations; electrostatic potential charges; atomic charges; ferrochelatase; cytochrome; myoglobin; Porphyrin; haem; QM MM; reorganisation energy; Theoretical chemistry; quantum chemistry; Teoretisk kemi; kvantkemi;

   Sammanfattning : Different aspects of porphyrin proteins have been studied with theoretical methods. For example, we have studied: - The importance of hydrogen bonds for the discrimination between carbon monoxide and molecular oxygen by myoglobin, the oxygen carrier in muscles, modelling the active site both in vacuum and in the protein matrix - The inner-sphere reorganisation energy during electron transfer for cytochromes compared to other electron-transfer proteins, such as blue copper proteins and Fe-S clusters - The role of porphyrin distortions in the reaction mechanism of ferrochelatase, the enzyme that inserts an iron ion into protoporphyrin IX to make haem - The interaction between different metal sites in ferrochelatase In these studies we have used density functional theory, classical force field methods, and a combination of quantum chemistry and molecular mechanics. LÄS MER

5. 4. Redox Reactions of NO and O2 in Iron Enzymes : A Density Functional Theory Study

   Författare :Mattias Blomberg; Per Siegbahn; Adrian Mulholland; Stockholms universitet; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; enzyme catalysis; redox reactions; cytochrome oxidase; nitric oxide reductase; hyponitrous acid anhydride; peroxynitrite; myoglobin; prostaglandin synthase; PGHS; NO; N2O; O2; CO; Chemical physics; Kemisk fysik;

   Sammanfattning : In the present thesis the density functional B3LYP has been used to study reactions of NO and O2 in redox active enzymes.Reduction of nitric oxide (NO) to nitrous oxide (N2O) is an important part in the bacterial energy conservation (denitrification). LÄS MER

7. 5. Sweet stability

   Författare :Kajsa Ahlgren; Chalmers tekniska högskola; []
   Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; myoglobin; lysozyme; amyloid fibrils; DSC; trehalose; protein denaturation; neutron scattering; glass transition; sucrose;

   Sammanfattning : The disaccharide trehalose is known for its ability to stabilise proteins by preventing aggregation and elevating their denaturation temperature, consequently avoiding unfolding. The folding and function of proteins are vital for many biological processes. LÄS MER