Sökning: "Myocardial reperfusion injury"

Visar resultat 16 - 20 av 35 avhandlingar innehållade orden Myocardial reperfusion injury.

  1. 16. Cardioprotective treatment strategies

    Författare :Jesper vanderPals; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ADC-1004; apyrase; Cardioprotection; ischemia reperfusion; hypothermia; t-PA;

    Sammanfattning : In myocardial ischemia-reperfusion (I/R) injury, complement activation, tissue plasminogen activator (t-PA) and extracellular adenosine triphosphate (ATP) release contribute to myocardial injury. ATP is degraded into adenosine by the enzyme apyrase, and adenosine possesses cardioprotective properties. LÄS MER

  3. 17. Cardioprotective mechanisms by inhibition of the HMG-CoA reductase pathway and stimulation of peroxisome proliferator-activated receptors in myocardial ischaemia-reperfusion

    Författare :Aliaksandr Bulhak; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Endothelial function; endothelin-1; geranylgeranyl pyrophosphate; HMG-CoA reductase; infarct size; ischaemiareperfusion injury; myeloperoxidase; myocardium; nitric oxide; nitric oxide synthase; peroxisome proliferator-activated receptor-alpha; -gamma; PPAR-alpha; -gamma-ligands; RhoA; statins.;

    Sammanfattning : Acute myocardial ischaemia causes metabolic changes and results in a rapid decrease in the energy available to the cell. This leads to cell injury that, depending on the length of the ischaemic time, is reversible or irreversible. LÄS MER

  4. 18. Electrocardiographic predictors of clinical outcome in ST-elevation myocardial infarction

    Författare :Marina Demidova; Kardiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Malignant ventricular arrhythmias, particularly ventricular fibrillation (VF), remain an important contributor to mortality in ST-elevation myocardial infarction (STEMI). The size of myocardial injury is one more important factor influencing the prognosis of STEMI patients. LÄS MER

  5. 19. Energy-metabolic aspects of ischemia and pre-treatment: studies in porcine myocardium

    Författare :Katarina Ahlström; Göteborgs universitet; []
    Nyckelord :myocardial ischemia; adenosine; preconditioning; carbon monoxide;

    Sammanfattning : The focus of this thesis is to clarify mechanisms involved in protective pre-treatment of ischemia by carbon monoxide (CO) and ischemic preconditioning (IP), so that new pro-tective therapies can be designed. This is studied in heart muscle, where the clinical gain would ultimately be to be able to prolong the period during a threatened myocardial infarction where permanent injury can be prevented. LÄS MER

  7. 20. Myocardial energy metabolism in ischemic preconditioning, role of adenosine catabolism

    Författare :Mohammad Kavianipour; Umeå universitet; []
    Nyckelord :Ischemic preconditioning; adenosine; purine nucleoside phosphorylase; microdialysis; pig; Medicine; medicin;

    Sammanfattning : Brief episodes of ischemia and reperfusion render the myocardium more resistant to necrosis from a subsequent, otherwise lethal ischemic insult. This phenomenon is called ischemic preconditioning(IP). LÄS MER