Sökning: "Myocardial reperfusion injury"

Visar resultat 11 - 15 av 35 avhandlingar innehållade orden Myocardial reperfusion injury.

  1. 11. Studies of myocardial ischaemia followed by reperfusion : new experimental models and their application

    Författare :Yozo Uriuda; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :myocardial infarction; myocardial ischaemia; reperfusion injury; animal experiment; rat; pig; dog; coronary venous retroinfusion; synchronised coronary venous retroperfusion; thrombosis; thrombolysis; inogatran; endothelin;

    Sammanfattning : Despite great efforts to reduce morbidity and mortality in ischaemic heart disease, this is still the most common cause of death in the industrialised countries. To improve the management of such patients, further knowledge is needed of the pathophysiology of ischaemic heart disease. LÄS MER

  3. 12. The importance of nitric oxide availability in myocardial ischemia-reperfusion injury : regulatory roles of arginase, L-arginine and tetrahydrobiopterin

    Författare :Yahor Tratsiakovich; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Background. Maintenance of nitric oxide (NO) availability is crucial for cardiovascular homeostasis and protection against myocardial ischemia-reperfusion (IR) injury. LÄS MER

  4. 13. The role of endothelin during myocardial ischaemia and reperfusion : pathophysiological mechanisms and interactions with nitric oxide

    Författare :Adrian T Gonon; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ischaemia; reperfusion injury; myocardium; infarct size; endothelium; endothelin; endothelin receptor; nitric oxide; nitric oxide synthase; polymorphonuclear leukocytes; myeloperoxidase; pig; rat;

    Sammanfattning : Acute myocardial infarction followed by reperfusion results in accelerated necrosis of irreversibly injured myocytes as well as induction of lethal injury to reversibly injured cells. Polymorphonuclear leukocytes (PMNs) are major participants in the reperfusion-initiated inflammation. LÄS MER

  5. 14. The importance of nitric oxide bioavailability and endothelial mechanisms for cardioprotection by pharmacological intervention during myocardial ischaemia and reperfusion

    Författare :Andrey Gourine; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :ATP sensitive K channels; endothelin-1; clevidipine; ETA receptor antagonist; glibenclamide; 5-hydroxydecanoic acid; infarct size; ischaemia; myeloperoxidase; nitric oxide; nitric oxide synthase; pig; preconditioning; rat; reperfusion.;

    Sammanfattning : Myocardial ischaemia initiates complex severe cellular changes and, after a critical time period, myocardial cell death. Despite that restitution of coronary blood flow is an absolute pre-requisite for tissue survival, myocardial reperfusion per se will also increase irreversible damage in the jeopardised myocardium. LÄS MER

  7. 15. Signal transduction in restenosis and myocardial protection by hyperoxia

    Författare :Arno Ruusalepp; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Neointima; inflammation; NF-kappaB; preconditioning; MAPK; nitric oxide;

    Sammanfattning : Ischemic heart disease is a major cause of morbidity and mortality in the western world. Revascularization of ischemic myocardium is essential for cell survival, and is performed by thrombolysis, percutaneous transluminal coronary angioplasty (PTCA) and by coronary artery bypass grafting. LÄS MER