Sökning: "Mycobacterium tuberculosis"

Visar resultat 6 - 10 av 109 avhandlingar innehållade orden Mycobacterium tuberculosis.

  1. 6. Drug resistance in mycobacterium tuberculosis

    Författare :Getahun Abate; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Multidrug-resistance; tuberculosis; cefepime; moxicillin-clavulanate; ethambutol; WIT; rifampicin; isoniazid; katG;

    Sammanfattning : Drug-resistant tuberculosis is a global public health problem. This investigation was performed to find ways of improving regimens that could be used for the treatment of drug- and multidrug-resistant TB and also to find a rapid method of diagnosis of drug resistant TB, particularly MDR-TB. Among 107 isolates of M. LÄS MER

  3. 7. Synthesis of O-linked Carbasugar Analogues of Galactofuranosides and N-linked Neodisaccharides

    Författare :Jens Frigell; Ian Cumpstey; George Fleet; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; carbasugar; galactofuranose; mycobacterium; tuberculosis; ring-closing metathesis; GlfT2; galactan; epoxide-opening; pseudodisaccharide; etherification; regioselective; carbohydrate; carbocycles; glycomimetics; glucosidase; neodisaccharides; Mitsunobu; Organic synthesis; Organisk syntes; organisk kemi; Organic Chemistry;

    Sammanfattning : In this thesis, carbohydrate mimicry is investigated through the syntheses of carbohydrate analogues and evaluation of their inhibitory effects on carbohydrate-processing enzymes. Galactofuranosides are interesting structures because they are common motifs in pathogenic microorganisms but not found in mammals. M. LÄS MER

  4. 8. Mycobacterium tuberculosis and HIV coinfection : Effects on innate immunity and strategies to boost the immune response

    Författare :Anna-Maria Andersson; Robert Blomgran Julinder; Marie Larsson; Olle Stendahl; Susanna Brighenti; Linköpings universitet; []
    Nyckelord :;

    Sammanfattning : Tuberculosis (TB) still remains a big threat today, being the leading cause of death by a single infectious agent. The TB epidemic is fueled by HIV along with the increasing drug-resistance which prolongs the already long treatment duration and decreases the success rate for curing TB. LÄS MER

  5. 9. Novel Pharmacometric Methods for Informed Tuberculosis Drug Development

    Författare :Oskar Clewe; Ulrika S.H. Simonsson; Mats O. Karlsson; Piet van der Graaf; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacokinetics; pharmacodynamics; PKPD; pharmacometric; nonlinear mixed-effects models; multistate tuberculosis pharmacometric model; general pharmacodynamic interaction model; general pulmonary distribution model; tuberculosis; rifampicin; isoniazid; ethambutol; Pharmaceutical Science; Farmaceutisk vetenskap;

    Sammanfattning : With approximately nine million new cases and the attributable cause of death of an estimated two millions people every year there is an urgent need for new and effective drugs and treatment regimens targeting tuberculosis. The tuberculosis drug development pathway is however not ideal, containing non-predictive model systems and unanswered questions that may increase the risk of failure during late-phase drug development. LÄS MER

  7. 10. Antimicrobial peptide therapy for tuberculosis infections

    Författare :Komal Umashankar Rao; Medicinsk mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; tuberculosis; antimicrobial peptides; mode of action; nanoparticles; novel therapy; membrane active peptides;

    Sammanfattning : Tuberculosis is a communicable disease that persists as a second leading cause for death, by an infectious agent. Several reasons contribute to this issue to this, of which an upsurge in antibiotic resistance is of top concern. Resistance patterns in the form of mono or multidrug resistance was reported to most clinical therapies at our disposal. LÄS MER