Sökning: "Mycobacterium tuberculosis"

Visar resultat 11 - 15 av 109 avhandlingar innehållade orden Mycobacterium tuberculosis.

1. 11. Targeting Mycobacterium tuberculosis Proteins: Structure and Function Studies of Five Essential Proteins

   Författare :Adrian Suarez Covarrubias; Sherry Mowbray; Torsten Unge; Pedro Alzari; Uppsala universitet; []
   Nyckelord :Cell and molecular biology; carbonic anhydrase; threonine synthase; FAS II; Rv0636; Rv1284; Rv1295; Rv3588c; Rv3778c; X-ray crystallography; Cell- och molekylärbiologi; Mycobacterium tuberculosis;

   Sammanfattning : This thesis describes the target selection, cloning, expression, purification, crystallization, structure and biochemical characterization of five essential Mycobacterium tuberculosis (Mtb) proteins. The search for drugs against the causal agent of tuberculosis is urgently needed and the targeting of essential genes is necessary to fulfill this goal. LÄS MER

3. 12. Drug-resistant Mycobacterium tuberculosis in Estonia

   Författare :Annika Krüüner; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :Tuberculosis; Estonia; M. tuberculosis; drug resistance; MDR-TB; Beijing genotype; cross-resistance; kanamycin; amikacin; rrs mutations; 16S rRNA; exposure; nosocomial transmission; mycobacterial persistence; re-infection; DST; second-line drugs; Bactec; 460; DNA fingerprinting; spoligotyping;

   Sammanfattning : Tuberculosis (TB) infection and disease patterns among different populations are extremely heterogeneous. This thesis explores mainly by microbiological methods the epidemiology of TB in Estonia. Through the work high rates of drug resistance were found. LÄS MER

4. 13. Mycobacterium tuberculosis and the human macrophage : shifting the balance through inflammasome activation

   Författare :Daniel Eklund; Maria Lerm; Olle Stendahl; Eva Särndahl; Norbert Reiling; Linköpings universitet; []
   Nyckelord :;

   Sammanfattning : Mycobacterium tuberculosis is a very successful pathogen and tuberculosis constitutes a major threat to global health worldwide. The World Health Organization (WHO) estimates that almost nine million new cases and 1. LÄS MER

5. 14. Structural Studies of a Xyloglucan Endotransglycosylase from Populus tremula x tremuloides and Three Conserved Hypothetical Proteins from Mycobacterium tuberculosis

   Författare :Patrik Johansson; Alwyn Jones; Sherry Mowbray; Pedro Alzari; Uppsala universitet; []
   Nyckelord :Cell and molecular biology; xyloglucan endotransglycosylase; Mycobacterium tuberculosis; epoxide hydrolase; fatty acid metabolism; fatty acid oxidation; crystallography; Cell- och molekylärbiologi;

   Sammanfattning : This thesis describes the structural studies of four different proteins from two organisms. Xyloglucan endotransglycosylases, XETs, are involved in plant cell wall expansion and remodeling by splitting and reconnecting xyloglucan-cellulose crosslinks. The first crystal structure of a XET enzyme has been determined to 1.8 Å. LÄS MER

7. 15. Molecular Palaeopathology : Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy

   Författare :Emilia Nuorala; Kerstin Lidén; Ingrid Ekenman; Marie Allen; Stockholms universitet; []
   Nyckelord :HUMANIORA; HUMANITIES; molecular palaeopathology; ancient DNA; disease; bacteria; tuberculosis; leprosy; Archaeology subjects; Arkeologiämnen;

   Sammanfattning : This thesis “Molecular Palaeopathology. Ancient DNA analyses of the bacterial diseases tuberculosis and leprosy” deals with molecular palaeopathology, i.e. in this case the use of molecular methods to analyse ancient bacterial DNA in order to get further knowledge of diseases in ancient times. LÄS MER