Sökning: "Muscarinic"

Visar resultat 1 - 5 av 90 avhandlingar innehållade ordet Muscarinic.

  1. 1. Muscarinic receptors : interactions with agonists and antagonists : synthesis, structure-activity relationships and molecular modeling

    Författare :Gunnar Nordvall; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; PHARMACY; FARMACI;

    Sammanfattning : .... LÄS MER

  3. 2. Muscarinic receptors and urinary bladder selectivity : Properties that determine the organ selectivity of compounds

    Författare :Staffan Sundquist; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical biosciences; bladder; muscarinic; receptor subtypes; smooth muscle; multivariate; Farmaceutisk biovetenskap; Biopharmacy; Biofarmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Urinary bladder contraction is mainly mediated by activation of muscarinic acetylcholine receptors (mAChR). Muscarinic antagonists are often effective in treatment of unstable bladder. The effectiveness of this treatment has often been limited by side effects as dry mouth. LÄS MER

  4. 3. Muscarinic acetylcholine receptors : investigation of interactions with agonists and antagonists

    Författare :Britta Hedlund; Stockholms universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES;

    Sammanfattning : In the present investigation interactions of agonists and antagonists with the muscarinic acetylcholine receptor from rat cerebral cortex and rat ileum smooth muscle have been characterized.It is suggested that the binding of antagonist involves two sequential equilibria, an association reaction followed by isomerization of the receptor-antagonist complex. LÄS MER

  5. 4. Muscarinic toxins from Dendroaspis (Mamba) venom : peptides selective for subtypes of muscarinic acetylcholine receptors

    Författare :Mikael Jolkkonen; Uppsala universitet; []
    Nyckelord :NATURAL SCIENCES; NATURVETENSKAP;

    Sammanfattning : .... LÄS MER

  7. 5. Investigation on Pre- and Postsynaptic Ca2+ Signaling in Neuronal Model Systems

    Författare :Jelena Krjukova; Åkerman Karl; Kukkonen Jyrki; Rydqvist Bo; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Physiology; calcium; neurotransmitter release; nicotine; depolarization; G-protein coupled receptor; muscarinic; phospholipase C; m-3M3FBS; Fysiologi; Physiology; Fysiologi;

    Sammanfattning : Communication between neuronal and non-neuronal is called volume transmission when the released neurotransmitter (NT) acts via diffusion and affects several target cells. Both the neurosecretory and postsynaptic cell responses are linked to [Ca2+]i elevations. LÄS MER