Sökning: "Muscarinic receptor subtype"
Visar resultat 11 - 14 av 14 avhandlingar innehållade orden Muscarinic receptor subtype.
11. Estrogen effects on different neurotransmitters in rat hippocampus : implications for cognitive function
Sammanfattning : The past decade has witnessed a growing interest in estrogens and their activity in the central nervous system, which extends beyond the reproductive functions. Estrogen is known to interact with different neurotransmitter systems. LÄS MER
12. Hippocampal galanin and acetylcholine in spatial learning
Sammanfattning : The aim of the present thesis was to study how the neuropeptide galanin affects the neurochemistry and functional activity of the cholinergic septohippocampal projection, which plays a pivotal role in learning and memory. This cholinergic system is strongly impaired in Alzheimer's disease and in age-related dementias. LÄS MER
13. Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : implications for Alzheimer’s disease
Sammanfattning : Alzheimer’s disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component is hyperphosphorylated tau. The degenerative progression seen in AD is accompanied by disturbances in several neurotransmitter systems, especially the cholinergic neurotransmitter system. LÄS MER
14. Novel pharmacological treatment alternatives for schizophrenia
Sammanfattning : Antipsychotic drugs are commonly divided into typical (first generation) and atypical (second generation) antipsychotic drugs. Clinically effective doses of typical antipsychotic drugs generate a striatal dopamine D2 receptor occupancy of about 70 80%, approaching a level that is associated with a high risk of extrapyramidal side effects. LÄS MER
