Sökning: "Murali K Akula"

Hittade 1 avhandling innehållade orden Murali K Akula.

1. 1. Defining the importance of protein geranylgeranylation in innate immunity

   Författare :Murali K Akula; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CAAX proteins; GGTase-I; RAC1; statins;

   Sammanfattning : RHO family proteins and other intracellular proteins are prenylated with a 20-carbon lipid—a product of the cholesterol synthesis pathway—by protein geranylgeranyltransferase type I (GGTase-I). Prenylation is widely believed to target proteins to membranes where they encounter effector molecules that stimulate GTP-binding and activation. LÄS MER