Sökning: "Multicenter Study"

Visar resultat 1 - 5 av 136 avhandlingar innehållade orden Multicenter Study.

1. 1. Impact of disease and treatment on body weight and eating in patients with head and neck cancer : experiences from a multicenter study

   Författare :Sandra Ottosson; Göran Laurell; Cecilia Olsson; Björn Zackrisson; Elisabeth Kjellén; Antti Mäkitie; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Head and neck cancer; weight loss; body mass index; tube feeding; radiation therapy; survival; treated volume; swallowing dysfunction; patient experience.; oto-rhino-laryngologi; Oto-Rhino-Laryngology;

   Sammanfattning : Background Nutritional deterioration in patients with head and neck cancer (HNC) has a multifactorial etiology mainly associated with tumor and treatment related factors. The objective of the present thesis was to investigate the impact of the disease and treatment on body weight and eating in patients with HNC treated with radiation therapy (RT) as the single modality treatment or as preoperative RT by analyzing body weight and body mass index (BMI) over time, predictive factors for weight loss and BMI, weight loss and BMI as prognostic factors for survival, and by studying the patients’ own experience of food and eating. LÄS MER

3. 2. Surgical and neurological adverse effects of epilepsy surgery

   Författare :Johan Bjellvi; Göteborgs universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; epilepsy surgery; invasive electrode procedures; intracranial EEG; complications; adverse events; risk; seizure worsening; multicenter study; register study; SNESUR;

   Sammanfattning : The aim of this thesis was to study surgical and neurological complications of preoperative invasive investigations and epilepsy surgery procedures (Papers I-II) and seizure worsening after epilepsy surgery (Paper III). A further aim was to improve reporting of adverse effects related to invasive investigations and epilepsy surgery by proposing and evaluating an evidence-based protocol for monitoring complications (Paper IV). LÄS MER

4. 3. Idiopathic polyneuropathy : a pathogenetic study

   Författare :Kristin Samuelsson; Karolinska Institutet; Karolinska Institutet; []
   Nyckelord :;

   Sammanfattning : Polyneuropathy (PNP) stands for dysfunction in the peripheral nerves. The classical clinical manifestations of PNP are distal, symmetric sensory symptoms, such as numbness and pain, as well as distal weakness in a sock- and glove pattern. For most patients with PNP, the progression rate is slow and the degree of impairment is limited. LÄS MER

5. 4. Health-related Quality of Life in Head and Neck Cancer. A Five-year Prospective Multicenter Study

   Författare :Mats Nordgren; allergi och livskvalitet Laryngoesofagologi; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; ; Health-related quality of life; hörsel- och talorganen; prospective; longitudinal; predictive factors; Medicine human and vertebrates ; Medicin människa och djur ; audiologi; auditive system and speech; Otorinolaryngologi; audiology; Otorhinolaryngology; head and neck cancer; EORTC QLQ-C30;

   Sammanfattning : The aim of this prospective longitudinal multicenter study was to evaluate the health-related quality of life (HRQL) in patients with head and neck cancer at diagnosis, after one and five years in relation to tumour location, stage, sub site, treatment modality, gender and age. The first part of the study, lasting for one year, consisted of 357 patients (mean age 63 years; 72% males) that were included between 1993 and 1995. LÄS MER

7. 5. Growth hormone responsiveness in children : results from Swedish multicenter clinical trials of growth hormone treatment

   Författare :Elena Lundberg; Berit Kriström; Kerstin Albertsson-Wikland; Roland Pfäffle; Umeå universitet; []
   Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; gain in height; puberty; IGHD; non-GHD; IGF-I; bioavailability;

   Sammanfattning : The general aims of the thesis were to study GH responsiveness by estimation of pharmacokinetics and bioavailability of injected recombinant human GH (rhGH), of growth response as gain in heightSDS during childhood and puberty, and IGF-I response as change in circulating IGF-ISDS and IGFBP3SDS. Methods Short children were recruited during 1988–1999 into two national randomized multicentre clinical trials on growth until adult height. LÄS MER