Sökning: "Muhammad Ali"

Visar resultat 1 - 5 av 7 avhandlingar innehållade orden Muhammad Ali.

  1. 1. Understanding Cancer Mutations by Genome Editing

    Författare :Muhammad Akhtar Ali; Tobias Associate Professor; Thierry Soussi; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genome editing; rAAV; ZBED6; DIP2C; KRAS; BRAF; colorectal cancer; tumor driver genes; cancer pathways;

    Sammanfattning : Mutational analyses of cancer genomes have identified novel candidate cancer genes with hitherto unknown function in cancer. To enable phenotyping of mutations in such genes, we have developed a scalable technology for gene knock-in and knock-out in human somatic cells based on recombination-mediated construct generation and a computational tool to design gene targeting constructs. LÄS MER

  3. 2. Identification of SLiMs: Mapping and characterizing motif-based protein interactions

    Författare :Muhammad Ali; Ylva Ivarsson; Shoshana Wodak; Uppsala universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; Phage display; protein-protein interactions; short linear motifs; PDZ; FERM; affinity; x-ray crystallization; molecular docking; NLS;

    Sammanfattning : During the last twenty years it has become evident that about 35-40% of amino acids in the proteome are in regions that have evolved to remain unstructured. These intrinsically disordered regions contain short linear motifs (SLiMs), which serve as docking sites for protein-protein interactions. LÄS MER

  4. 3. Analysis of Sub-Synchronous Oscillations in Wind Power Plants

    Författare :Muhammad Taha Ali; Mehrdad Ghandari; Massimo Bongiorno; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Doubly fed Induction generator; eigenvalue analysis; sub-synchronous control interaction; voltage source converter; Electrical Engineering; Elektro- och systemteknik;

    Sammanfattning : The modern power system is moving towards the high integration of renewable energy sources at a fast pace. The integration of wind power in the power system raises many challenges along with the benefits. One of the recent challenges is the sub-synchronous oscillation (SSO) that occurs in doubly-fed induction generator (DFIG) based wind farms. LÄS MER

  5. 4. Dynamically Reconfigurable Resource Array

    Författare :Muhammad Ali Shami; Ahmed Hemani; S.K Nandy; KTH; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; DRRA; CGRA; FPGA; VLSI; ASIC; Embedded systems; Coarse grain reconfigurable architecture; reconfigurable computing;

    Sammanfattning : The goals set by the International Technology Roadmap for Semiconductors (ITRS) for the consumer portable category, to be realized by 2020, are 1000X improvement in performance with only 40\% increase in power budget and no increase in design team size. To meet these goals, the challenges facing the VLSI community are gaps in architecture efficacy, design productivity and battery capacity. LÄS MER

  7. 5. Towards Measuring & Improving Source Code Quality

    Författare :Umar Iftikhar; Nauman bin Ali; Jürgen Börstler; Muhammad Usman; Miroslaw Ochodek; Blekinge Tekniska Högskola; []
    Nyckelord :TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Source code quality; Code review analysis; Software quality improvement; Programvaruteknik; Software Engineering;

    Sammanfattning : Context: Software quality has a multi-faceted description encompassing several quality attributes. Central to our efforts to enhance software quality is to improve the quality of the source code. Poor source code quality impacts the quality of the delivered product. LÄS MER