Sökning: "Mucosal immune response"

Visar resultat 21 - 25 av 127 avhandlingar innehållade orden Mucosal immune response.

  1. 21. The small intestine in experimental peritonitis : An experimental study focusing om intestinal energy metabolism, bacterial translocation and mucosal immunology

    Författare :Mikael Ljungdahl; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Surgery; Bacterial translocation; endotoxin; faecal peritonitis; high-energy phosphates; hypoxia; intramucosal pH; IL-6; ischaemia; lactate; lymphocytes; mucosal injury; oxygendelivery; pigs; sepsis; tonometry; Kirurgi; Surgery; Kirurgi; Surgery; kirurgi;

    Sammanfattning : The gut is highly susceptible to injury during sepsis. An impaired mucosal barrier permitstranslocation of enteric microorganisms to blood or other organs. In a porcine model sepsiswas induced by faecal peritonitis. LÄS MER

  3. 22. Mucosal T-cell and cytokine responses in Helicobacter pylori-infected duodenal ulcer patients

    Författare :Erika Strömberg; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Helicobacter pylori; mucosal immunology; antrum; duodenum; duodenal ulcer; asymptomatic; epithelial cells; cytokines; T cells;

    Sammanfattning : Helicobacter pylori colonizes the human stomach and areas of gastric metaplasia in the duodenum. The bacterium is the major cause of chronic active gastritis and peptic ulcer disease and is a risk factor for the development of gastric adenocarcinoma and lymphoma. LÄS MER

  4. 23. B- and T- cell responses in colectomized and healthy individuals after mucosal vaccination

    Författare :Jan Kilhamn; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; intestinal immunity; antibodies; interferon gamma production; ileostomy fluid; enteric vaccines; mucosal vaccination;

    Sammanfattning : The overall aims were to study the induction of intestinal and systemic B- and T-cell immune responses in patients colectomized due to ulcerative colitis and in healthy volunteers after mucosal administration of enteric vaccines. An inactivated B-subunit whole-cell (B-WC) cholera vaccine and a live attenuated Salmonella enterica serovar Typhi Ty21a vaccine were used as model immunogens. LÄS MER

  5. 24. Nasal vaccination using novel mucosal adjuvants : with main focus on influenza A virus

    Författare :Tina Falkeborn; Jorma Hinkula; Marie Larsson; Britt Åkerlind; Anders Wallensten; Linköpings universitet; []
    Nyckelord :NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Influenza viruses have sporadically caused pandemics during the last century, with the most severe occurring in 1918 when the “Spanish flu”, an A/H1N1 influenza virus, passed around the globe killing about 20-100 million people. Today 250 000-500 000 deaths occur annually due to influenza virus or secondary infection after influenza, e.g. LÄS MER

  7. 25. Mucosal Vaccination Using Polyacryl Starch Microparticles as Adjuvant with Salmonella enteritidis as a Model Pathogen

    Författare :Lena Strindelius; Ingvar Sjöholm; Mary Jo Wick; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutics; mucosal vaccination; polyacryl starch microparticles; salmonella enteritidis; flagellin; fimbriae; rCTB; LPS; Ussing chamber; Galenisk farmaci; Pharmaceutics; Galenisk farmaci; galenisk farmaci; Pharmaceutics;

    Sammanfattning : Polyacryl starch microparticles have been developed as a new mucosal vaccine adjuvant intended for use in oral vaccination. The main objectives of this thesis were to evaluate the efficacy of these polyacryl starch microparticles and to study their uptake through mucosal tissues. LÄS MER