Sökning: "Mucosal host response"

Visar resultat 16 - 20 av 58 avhandlingar innehållade orden Mucosal host response.

  1. 16. Helicobacter pylori interference with the L-arginine/NO pathway in the upper gut

    Författare :Charlotte Von Bothmer; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; acid; bicarbonate; duodenal ulcer; Helicobacter pylori; host defence; mucosa; nitric oxide; nitric oxide synthase;

    Sammanfattning : Helicobacter pylori causes chronic gastritis and sometimes peptic ulcers but the pathogenesis is not fully understood. H. pylori-infected individuals with duodenal ulcer have an impaired duodenal mucosal bicarbonate secretion (DMBS) in response to acid. NO is an important signalling molecule in the body. LÄS MER

  3. 17. Tear Secretory IgA: A Noninvasive Biomarker of Mucosal Immune Competence

    Författare :Helen Hanstock; Neil Walsh; Michael Gleeson; Bangor University; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Sammanfattning : Since early studies investigated the influence of exercise on salivary secretory IgA(SIgA) in the 1980s, there has been demand for non-invasive biomarkers capableof monitoring the immune response to exercise, training and stress, and provideinsight into whether such stressors may influence susceptibility to URTI. In spiteof >30 years of research and ~200 original articles investigating a multitude ofcandidate markers, this tool remains elusive. LÄS MER

  4. 18. Regulation of gut IgA induction by helper T cells

    Författare :Inta Gribonika; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mucosal immunology; secretory IgA; T regulatory cells; T follicular helper cells; Th17 cells; Peyer s patches; IgA class-switch recombination; germinal centers;

    Sammanfattning : The gut is the largest lymphoid organ in the body. Due to intense and constant exposure to the outside world, it also functions as the most important portal of entry for many pathogens. LÄS MER

  5. 19. Influence of host genetics on innate immunity and susceptibility to urinary tract infection

    Författare :Bryndis Ragnarsdottir; immunologi och glykobiologi - MIG Avdelningen för mikrobiologi; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; neutrophils; IRF3; Innate Immunity; urinary tract infections; acute pyelonephritis; asymptomatic bacteriuria; Toll-like receptor 4; CXCR1; TLR4 adaptors; polymorphisms;

    Sammanfattning : It has been known for a long time that the clinical manifestations of urinary tract infections (UTI) differ markedly between individuals, ranging from a sometimes beneficial, asymptomatic state to life threatening infections. This variability in clinical manifestation can be explained in part by the arsenal of virulence factors of the bacteria but the predisposition of the patient is equally important. LÄS MER

  7. 20. The development of a new combined adjuvant vector for mucosal immunization CTA1-DD/ISCOM

    Författare :Anja Helgeby; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CTA1-DD; ISCOM; adjuvants; enzyme; vaccine; B cell; Dendritic cell; T cells;

    Sammanfattning : The CTA1-DD/ISCOMs vector is a rationally designed mucosal adjuvant that was developed to host the distinctive properties of either adjuvant alone or in a combination that hosted additive enhancing effects on mucosal immune responses. Here I demonstrate that CTA1-DD can be incorporated into the ISCOM with greatly augmented immunogenicity of both incorporated and admixed antigen. LÄS MER