Sökning: "Mouse exposure"

Visar resultat 11 - 15 av 193 avhandlingar innehållade orden Mouse exposure.

  1. 11. Cataract from ultraviolet radiation in the mouse

    Författare :Linda Maren Meyer; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :Lens; cataract; ultraviolet radiation; oxidative stress; mouse; light scattering;

    Sammanfattning : Cataract is defined as an opacification of the crystalline lens that results in visual impairment, Cataract is the number one cause of blindness in the world and there are currently no strategies to prevent it. Extraction of cataractogenous lenses is the most commonly performed surgical intervention in industrialized countries. LÄS MER

  3. 12. Radiobiological effects of the thyroid gland - transcriptomic and proteomic responses to 131l and 211At exposure

    Författare :Nils Rudqvist; Göteborgs universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; astatine-211; iodine-131; radionuclide therapy; nuclear medicine; environmental exposure; thyroid; radiation biology; transcriptomics; proteomics; ionizing radiation; toxicity; normal tissue damage; microarray; LC-MS; biomarker;

    Sammanfattning : Radionuclides are widely used in medicine. 131I is one of the most employed radionuclides and is administered to patients either bound to tumor targeting molecules or as halide to target the thyroid or thyroid cancer. LÄS MER

  4. 13. Automated behavioral phenotyping of inbred mouse strains and mouse models of Alzheimer disease

    Författare :Alina Codita; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Behavioral characterization of various mouse strains created as models for human diseases such as Alzheimer disease requires robust phenotyping methods. Previous work on inbred mouse strains has shown that some of the widely used behavioral methods yield inconsistent results across laboratories, in spite of standardization efforts. LÄS MER

  5. 14. Effects of Antioxidants and Pro-oxidants on Oxidative Stress and DNA Damage using the Comet Assay : Studies on Blood Cells from Type 2 Diabetes Subjects and Mouse Lymphoma Cells

    Författare :Rikard Åsgård; Björn Hellman; Leif Busk; Uppsala universitet; []
    Nyckelord :MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; metabolic syndrome; fruit and vegetable intake; plasma antioxidants; beta-carotene; alpha-tocopherol; inflammation; oxidative DNA damage; lipid peroxidation; mouse lymphoma assay; ROS; nucleotide pool; viability; DNA dye; Toxicology; Toxikologi;

    Sammanfattning : Diet and oral supplements comprise two distinct sources of antioxidants known to prevent oxidative stress. Beneficial effects from antioxidants have been seen for patients at risk for type 2 diabetes.The aim of this thesis was to evaluate the positive effects of antioxidants against oxidative stress and DNA damage in type 2 diabetes subjects. LÄS MER

  7. 15. Modeling PDGF-driven gliomagenesis in the mouse

    Författare :Inga Nazarenko; Karolinska Institutet; Karolinska Institutet; []
    Nyckelord :;

    Sammanfattning : Gliomas are the most common form of brain tumors, with glioblastoma being the most aggressive form. Glioblastoma is characterized by a number of genetic aberrations, among them amplification and overexpression of platelet-derived growth factor receptor alpha (PDGFRA) that sometimes occurs together with inactivating mutations or loss of the tumor suppressor p53 (TP53). LÄS MER